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  The Spo13/Meikin pathway confines the onset of gamete differentiation to meiosis II in yeast

Oz, T., Mengoli, V., Rojas, J., Jonak, K., Braun, M., Zagoriy, I., et al. (2022). The Spo13/Meikin pathway confines the onset of gamete differentiation to meiosis II in yeast. EMBO Journal, 41(4): e109446, pp. 23. doi:10.15252/embj.2021109446.

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 Creators:
Oz, T., Author
Mengoli, V., Author
Rojas, J., Author
Jonak, K., Author
Braun, Marianne1, Author           
Zagoriy, I., Author
Zachariae, Wolfgang, Author
Affiliations:
1EM-Histo Lab / MPI Neurobiology, ou_persistent22              

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Free keywords: gametogenesis meiosis II polo-like kinase Cdc5 Spo13 Meikin spore differentiation spindle pole body anaphase-promoting complex casein kinase 1 chromosome segregation cell-cycle homologous chromosomes translational control kinetochore protein prospore membrane spermatid differentiation Biochemistry & Molecular Biology Cell Biology
 Abstract: Sexual reproduction requires genome haploidization by the two divisions of meiosis and a differentiation program to generate gametes. Here, we have investigated how sporulation, the yeast equivalent of gamete differentiation, is coordinated with progression through meiosis. Spore differentiation is initiated at metaphase II when a membrane-nucleating structure, called the meiotic plaque, is assembled at the centrosome. While all components of this structure accumulate already at entry into meiosis I, they cannot assemble because centrosomes are occupied by Spc72, the receptor of the gamma-tubulin complex. Spc72 is removed from centrosomes by a pathway that depends on the polo-like kinase Cdc5 and the meiosis-specific kinase Ime2, which is unleashed by the degradation of Spo13/Meikin upon activation of the anaphase-promoting complex at anaphase I. Meiotic plaques are finally assembled upon reactivation of Cdk1 at entry into metaphase II. This unblocking-activation mechanism ensures that only single-copy genomes are packaged into spores and might serve as a paradigm for the regulation of other meiosis II-specific processes.

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Language(s): eng - English
 Dates: 2022-02-15
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: Other: WOS:000741988200001
DOI: 10.15252/embj.2021109446
ISSN: 0261-4189
 Degree: -

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Title: EMBO Journal
  Other : EMBO J.
Source Genre: Journal
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Publ. Info: Nature Publishing Group
Pages: - Volume / Issue: 41 (4) Sequence Number: e109446 Start / End Page: 23 Identifier: ISSN: 0261-4189
CoNE: https://pure.mpg.de/cone/journals/resource/954925497061