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  Where did my Cheese Move? Behavioural and Hippocampal Traces of Uncertainties Induced by Changes in Reward Distributions

Xuan, F., Tessereau, C., Ashby, M., Clopath, C., Jones, M., Mainen, Z., et al. (2022). Where did my Cheese Move? Behavioural and Hippocampal Traces of Uncertainties Induced by Changes in Reward Distributions. Poster presented at FENS Forum 2022, Paris, France.

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Xuan, F, Author
Tessereau, C1, Author           
Ashby, M, Author
Clopath, C, Author
Jones, M, Author
Mainen, Z, Author
Pickering, T, Author
Walton, M, Author
Mellor, J, Author
Dayan, P1, Author           
Dombeck, D, Author
Affiliations:
1Department of Computational Neuroscience, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_3017468              

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 Abstract: New, changing, and inherently variable environments force animals to address different sorts of uncertainty. These in turn, are associated with various aspects of behavioural and neural activity. Hippocampal place cells code in a behaviourallyrelevant manner for aspects of space and reward. By inducing various forms of uncertainty in these two quantities, we sought to shed light on the ways that mice experience and accommodate the incompletely known. We designed a novel Uncertain Reward Task (URTask) in a virtual reality (VR) apparatus (figure1). Mice (six adults) were trained to run along a VR linear track and lick for a water reward. Different forms of uncertainty were manipulated by varying the distributions of reward locations and changing the virtual surround. Using two-photon calcium imaging, we recorded activities of place cells in CA1 along with mouse behaviour (licking and velocity) as uncertainty was induced and partially resolved by experience. Given inherently variable reward locations, animals tend to slow down and lick continuously within the expected reward zone (figure 2), and the place map within the reward zone becomes less spatially precise (figure 3). From limpid changes in reward locations, the behaviour requires a few trials to adjust to the new task configuration (figure 4), and the place map undergoes a higher degree of remapping (figure 5). Our data demonstrates that the URTask can engender different forms of uncertainty that produce different behavioural and neuronal adaptations. The URTask may therefore be used to investigate how the brain distinguishes and decodes varying forms of uncertainty.

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 Dates: 2022-07
 Publication Status: Published online
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Title: FENS Forum 2022
Place of Event: Paris, France
Start-/End Date: 2022-07-09 - 2022-07-13

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Title: FENS Forum 2022
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: S01-080 Start / End Page: 389 - 391 Identifier: -