English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
Add to Basket
 Local TagsRelease HistoryDetailsSummary
  Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals

Winkler, T. W., Rasheed, H., Teumer, A., Gorski, M., Rowan, B. X., Stanzick, K. J., et al. (2022). Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals. COMMUNICATIONS BIOLOGY, 5(1): 580. doi:10.1038/s42003-022-03448-z.

Item is

 

show all hide all

Basic

show hide
Item Permalink: https://hdl.handle.net/21.11116/0000-000A-B93E-1 Version Permalink: https://hdl.handle.net/21.11116/0000-000A-B93F-0
Genre: Journal Article

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Winkler, Thomas W., Author
Rasheed, Humaira, Author
Teumer, Alexander, Author
Gorski, Mathias, Author
Rowan, Bryce X., Author
Stanzick, Kira J., Author
Thomas, Laurent F., Author
Tin, Adrienne, Author
Hoppmann, Anselm, Author
Chu, Audrey Y., Author
Tayo, Bamidele, Author
Thio, Chris H. L., Author
Cusi, Daniele, Author
Chai, Jin-Fang, Author
Sieber, Karsten B., Author
Horn, Katrin, Author
Li, Man, Author
Scholz, Markus, Author
Cocca, Massimiliano, Author
Wuttke, Matthias, Author
van der Most, Peter J., AuthorYang, Qiong, AuthorGhasemi, Sahar, AuthorNutile, Teresa, AuthorLi, Yong, AuthorPontali, Giulia, AuthorGuenther, Felix, AuthorDehghan, Abbas, AuthorCorrea, Adolfo, AuthorParsa, Afshin, AuthorFeresin, Agnese, Authorde Vries, Aiko P. J., AuthorZonderman, Alan B., AuthorSmith V, Albert, AuthorOldehinkel, Albertine J., AuthorDe Grandi, Alessandro, AuthorRosenkranz, Alexander R., AuthorFranke, Andre, AuthorTeren, Andrej, AuthorMetspalu, Andres, AuthorHicks, Andrew A., AuthorMorris, Andrew P., AuthorToenjes, Anke, AuthorMorgan, Anna, AuthorPodgornaia I, Anna, AuthorPeters, Annette, AuthorKoerner, Antje, AuthorMahajan, Anubha, AuthorCampbell, Archie, AuthorFreedman I, Barry, AuthorSpedicati, Beatrice, AuthorPonte, Belen, AuthorSchoettker, Ben, AuthorBrumpton, Ben, AuthorBanas, Bernhard, AuthorKraemer, Bernhard K., AuthorJung, Bettina, AuthorAsvold, Bjorn Olav, AuthorSmith, Blair H., AuthorNing, Boting, AuthorPenninx, Brenda W. J. H., AuthorVanderwerff, Brett R., AuthorPsaty, Bruce M., AuthorKammerer, Candace M., AuthorLangefeld, Carl D., AuthorHayward, Caroline, AuthorSpracklen, Cassandra N., AuthorRobinson-Cohen, Cassianne, AuthorHartman, Catharina A., AuthorLindgren, Cecilia M., AuthorWang, Chaolong, AuthorSabanayagam, Charumathi, AuthorHeng, Chew-Kiat, AuthorLanzani, Chiara, AuthorKhor, Chiea-Chuen, AuthorCheng, Ching-Yu, AuthorFuchsberger, Christian, AuthorGieger, Christian, AuthorShaffer, Christian M., AuthorSchulz, Christina-Alexandra, AuthorWiller, Cristen J., AuthorChasman I, Daniel, AuthorGudbjartsson, Daniel F., AuthorRuggiero, Daniela, AuthorToniolo, Daniela, AuthorCzamara, Darina1, Author           Porteous, David J., AuthorWaterworth, Dawn M., AuthorMascalzoni, Deborah, AuthorMook-Kanamori, Dennis O., AuthorReilly, Dermot F., AuthorDaw, E. Warwick, AuthorHofer, Edith, AuthorBoerwinkle, Eric, AuthorSalvi, Erika, AuthorBottinger, Erwin P., AuthorTai, E-Shyong, AuthorCatamo, Eulalia, AuthorRizzi, Federica, AuthorGuo, Feng, AuthorRivadeneira, Fernando, AuthorGuilianini, Franco, AuthorSveinbjornsson, Gardar, AuthorEhret, Georg, AuthorWaeber, Gerard, AuthorBiino, Ginevra, AuthorGirotto, Giorgia, AuthorPistis, Giorgio, AuthorNadkarni, Girish N., AuthorDelgado, Graciela E., AuthorMontgomery, Grant W., AuthorSnieder, Harold, AuthorCampbell, Harry, AuthorWhite, Harvey D., AuthorGao, He, AuthorStringham, Heather M., AuthorSchmidt, Helena, AuthorLi, Hengtong, AuthorBrenner, Hermann, AuthorHolm, Hilma, AuthorKirsten, Holgen, AuthorKramer, Holly, AuthorRudan, Igor, AuthorNolte, Ilja M., AuthorTzoulaki, Ioanna, AuthorOlafsson, Isleifur, AuthorMartins, Jade1, Author           Cook, James P., AuthorWilson, James F., AuthorHalbritter, Jan, AuthorFelix, Janine F., AuthorDivers, Jasmin, AuthorKooner, Jaspal S., AuthorLee, Jeannette Jen-Mai, AuthorO'Connell, Jeffrey, AuthorRotter I, Jerome, AuthorLiu, Jianjun, AuthorXu, Jie, AuthorThiery, Joachim, AuthorArnlov, Johan, AuthorKuusisto, Johanna, AuthorJakobsdottir, Johanna, AuthorTremblay, Johanne, AuthorChambers, John C., AuthorWhitfield, John B., AuthorGaziano, John M., AuthorMarten, Jonathan, AuthorCoresh, Josef, AuthorJonas, Jost B., AuthorMychaleckyj, Josyf C., AuthorChristensen, Kaare, AuthorEckardt, Kai-Uwe, AuthorMohlke, Karen L., AuthorEndlich, Karlhans, AuthorDittrich, Katalin, AuthorRyan, Kathleen A., AuthorRice, Kenneth M., AuthorTaylor, Kent D., AuthorHo, Kevin, AuthorNikus, Kjell, AuthorMatsuda, Koichi, AuthorStrauch, Konstantin, AuthorMiliku, Kozeta, AuthorHveem, Kristian, AuthorLind, Lars, AuthorWallentin, Lars, AuthorYerges-Armstrong, Laura M., AuthorRaffield, Laura M., AuthorPhillips, Lawrence S., AuthorLauner, Lenore J., AuthorLyytikainen, Leo-Pekka, AuthorLange, Leslie A., AuthorCitterio, Lorena, AuthorKlaric, Lucija, AuthorIkram, M. Arfan, AuthorIsing, Marcus2, Author           Kleber, Marcus E., AuthorFrancescatto, Margherita, AuthorConcas, Maria Pina, AuthorCiullo, Marina, AuthorPiratsu, Mario, AuthorOrho-Melander, Marju, AuthorLaakso, Markku, AuthorLoeffler, Markus, AuthorPerola, Markus, Authorde Borst, Martin H., AuthorGogele, Martin, AuthorLa Bianca, Martina, AuthorLukas, Mary Ann, AuthorFeitosa, Mary F., AuthorBiggs, Mary L., AuthorWojczynski, Mary K., AuthorKavousi, Maryam, AuthorKanai, Masahiro, AuthorAkiyama, Masato, AuthorYasuda, Masayuki, AuthorNauck, Matthias, AuthorWaldenberger, Melanie, AuthorChee, Miao-Li, AuthorChee, Miao-Ling, AuthorBoehnke, Michael, AuthorPreuss, Michael H., AuthorStumvoll, Michael, AuthorProvince, Michael A., AuthorEvans, Michele K., AuthorO'Donoghue, Michelle L., AuthorKubo, Michiaki, AuthorKahonen, Mika, AuthorKastarinen, Mika, AuthorNalls, Mike A., AuthorKuokkanen, Mikko, AuthorGhanbari, Mohsen, AuthorBochud, Murielle, AuthorJosyula, Navya Shilpa, AuthorMartin, Nicholas G., AuthorTan, Nicholas Y. Q., AuthorPalmer, Nicholette D., AuthorPirastu, Nicola, AuthorSchupf, Nicole, AuthorVerweij, Niek, AuthorHutri-Kahonen, Nina, AuthorMononen, Nina, AuthorBansal, Nisha, AuthorDevuyst, Olivier, AuthorMelander, Olle, AuthorRaitakari, Olli T., AuthorPolasek, Ozren, AuthorManunta, Paolo, AuthorGasparini, Paolo, AuthorMishra, Pashupati P., AuthorSulem, Patrick, AuthorMagnusson, Patrik K. E., AuthorElliott, Paul, AuthorRidker, Paul M., AuthorHamet, Pavel, AuthorSvensson, Per O., AuthorJoshi, Peter K., AuthorKovacs, Peter, AuthorPramstaller, Peter P., AuthorRossing, Peter, AuthorVollenweider, Peter, Authorvan der Harst, Pim, AuthorDorajoo, Rajkumar, AuthorSim, Ralene Z. H., AuthorBurkhardt, Ralph, AuthorTao, Ran, AuthorNoordam, Raymond, AuthorMagi, Reedik, AuthorSchmidt, Reinhold, Authorde Mutsert, Renee, AuthorRueedi, Rico, Authorvan Dam, Rob M., AuthorCarroll, Robert J., AuthorGansevoort, Ron T., AuthorLoos, Ruth J. F., AuthorFelicita, Sala Cinzia, AuthorSedaghat, Sanaz, AuthorPadmanabhan, Sandosh, AuthorFreitag-Wolf, Sandra, AuthorPendergrass, Sarah A., AuthorGraham, Sarah E., AuthorGordon, Scott D., AuthorHwang, Shih-Jen, AuthorKerr, Shona M., AuthorVaccargiu, Simona, AuthorPatil, Snehal B., AuthorHallan, Stein, AuthorBakker, Stephan J. L., AuthorLim, Su-Chi, AuthorLucae, Susanne2, Author           Vogelezang, Suzanne, AuthorBergmann, Sven, AuthorCorre, Tanguy, AuthorAhluwalia, Tarunveer S., AuthorLehtimaki, Terho, AuthorBoutin, Thibaud S., AuthorMeitinger, Thomas, AuthorWong, Tien-Yin, AuthorBergler, Tobias, AuthorRabelink, Ton J., AuthorEsko, Tonu, AuthorHaller, Toomas, AuthorThorsteinsdottir, Unnur, AuthorVoelker, Uwe, AuthorFoo, Valencia Hui Xian, AuthorSalomaa, Veikko, AuthorVitart, Veronique, AuthorGiedraitis, Vilmantas, AuthorGudnason, Vilmundur, AuthorJaddoe, Vincent W. V., AuthorHuang, Wei, AuthorZhang, Weihua, AuthorWei, Wen Bin, AuthorKiess, Wieland, AuthorMarz, Winfried, AuthorKoenig, Wolfgang, AuthorLieb, Wolfgang, AuthorGao, Xin, AuthorSim, Xueling, AuthorWang, Ya Xing, AuthorFriedlander, Yechiel, AuthorTham, Yih-Chung, AuthorKamatani, Yoichiro, AuthorOkada, Yukinori, AuthorMilaneschi, Yuri, AuthorYu, Zhi, AuthorStark, Klaus J., AuthorStefansson, Kari, AuthorBoeger, Carsten A., AuthorHung, Adriana M., AuthorKronenberg, Florian, AuthorKoettgen, Anna, AuthorPattaro, Cristian, AuthorHeid, Iris M., Author more..
Affiliations:
1Dept. Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society, ou_2035295              
2Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137              

Content

show
hide
Free keywords: -
 Abstract: A large-scale GWAS provides insight on diabetes-dependent genetic effects on the glomerular filtration rate, a common metric to monitor kidney health in disease.
Reduced glomerular filtration rate (GFR) can progress to kidney failure. Risk factors include genetics and diabetes mellitus (DM), but little is known about their interaction. We conducted genome-wide association meta-analyses for estimated GFR based on serum creatinine (eGFR), separately for individuals with or without DM (n(DM) = 178,691, n(noDM) = 1,296,113). Our genome-wide searches identified (i) seven eGFR loci with significant DM/noDM-difference, (ii) four additional novel loci with suggestive difference and (iii) 28 further novel loci (including CUBN) by allowing for potential difference. GWAS on eGFR among DM individuals identified 2 known and 27 potentially responsible loci for diabetic kidney disease. Gene prioritization highlighted 18 genes that may inform reno-protective drug development. We highlight the existence of DM-only and noDM-only effects, which can inform about the target group, if respective genes are advanced as drug targets. Largely shared effects suggest that most drug interventions to alter eGFR should be effective in DM and noDM.

Details

show
hide
Language(s):
 Dates: 2022
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000810675200002
DOI: 10.1038/s42003-022-03448-z
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: COMMUNICATIONS BIOLOGY
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 5 (1) Sequence Number: 580 Start / End Page: - Identifier: -