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  No effects of prefrontal multichannel tACS at individual alpha frequency on phonological decisions

Werchowski, M., Stenner, T., Splittgerber, M., Siniatchkin, M., Nees, F., Hartwigsen, G., et al. (2022). No effects of prefrontal multichannel tACS at individual alpha frequency on phonological decisions. Clinical Neurophysiology, 142, 96-108. doi:10.1016/j.clinph.2022.07.494.

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 Creators:
Werchowski, Michael1, Author
Stenner, Tristan1, Author
Splittgerber, Meike1, Author
Siniatchkin, Michael1, 2, Author
Nees, Frauke1, Author
Hartwigsen, Gesa3, Author           
Moliadze, Vera1, Author
Affiliations:
1Institute of Medical Psychology and Medical Sociology, University Hospital of Schleswig-Holstein, Kiel, Germany, ou_persistent22              
2Clinic for Child and Adolescent Psychiatry and Psychotherapy, Medical Center Bethel, Bielefeld, Germany, ou_persistent22              
3Lise Meitner Research Group Cognition and Plasticity, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_3025665              

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Free keywords: Alpha; Transcranial alternating current stimulation; Individual alpha frequency; Prefrontal cortex; Neurostimulation; Dyslexia
 Abstract: Objective


Alpha oscillations are linked to inhibitory capabilities in higher cognitive processing. Transcranial alternating current stimulation (tACS) at 10 Hz can enhance alpha oscillations and modulate behaviour. One possibility to increase the efficacy of tACS may be stimulating at the individual alpha frequency (IAF). The present work addresses this issue (among others) to increase the current understanding of the functional role of alpha oscillations in higher cognitive tasks.





Methods


Twenty-two healthy and 13 dyslexic participants performed two word decision tasks while receiving IAF-tACS over the left prefrontal cortex. Resting EEG was recorded to detect electrophysiological changes. Cortical excitability was assessed with TMS.





Results


Dyslexic participants performed worse in the phonological task. However, no significant tACS effects were found. Interestingly, higher cortical excitability was correlated with faster responses in healthy controls. In dyslexics this association significantly differed in the phonological task.





Conclusion


The non-significant modulation by tACS might be explained by methodological limitations. Alternatively, it may indicate that alpha oscillations do not play a functional role in phonological decisions. The findings on cortical excitability expands the existing literature and may reflect the specific phonological deficit in dyslexics.





Significance


Our critical discussion of these null findings expands the systematic knowledge on alpha-tACS for future studies.

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Language(s): eng - English
 Dates: 2022-07-172022-07-302022-10
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/j.clinph.2022.07.494
Other: epub 2022
PMID: 36029581
 Degree: -

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Grant ID : -
Funding program : -
Funding organization : Max Planck Society
Project name : -
Grant ID : HA 6314/4-2; HA 6314/9-1
Funding program : -
Funding organization : German Research Foundation (DFG)

Source 1

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Title: Clinical Neurophysiology
  Other : Clin. Neurophysiol.
Source Genre: Journal
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Affiliations:
Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: 142 Sequence Number: - Start / End Page: 96 - 108 Identifier: ISSN: 1388-2457
CoNE: https://pure.mpg.de/cone/journals/resource/954926941726