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  Long-term changes in depressive symptoms before and after stroke

Blöchl, M., & Nestler, S. (2022). Long-term changes in depressive symptoms before and after stroke. Neurology, 99(7), e720-e729. doi:10.1212/WNL.0000000000200756.

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 Creators:
Blöchl, Maria1, 2, 3, Author           
Nestler, Steffen1, Author
Affiliations:
1Department of Psychology, Münster University, Germany, ou_persistent22              
2International Max Planck Research School on Neuroscience of Communication: Function, Structure, and Plasticity, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_2616696              
3Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              

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 Abstract: Objectives: To determine the trajectory of depressive symptoms several years before and after incident stroke. Method: We analysed data from 10,797 participants from the English Longitudinal Study of Ageing (ELSA) without a history of stroke at baseline (wave 1). We matched participants with incident stroke during the 12-year follow-up (waves 2-7) to stroke-free individuals using propensity scores accounting for age, gender, education, ethnicity, and vascular risk factors. Trajectories of depressive symptoms before and after stroke were analysed using multilevel models. Results: Among the 10,797 participants (mean age 64.6 ± 9.9 years, 54.8 % women), we identified 425 individuals with incident stroke. At the assessment before stroke, these individuals demonstrated an increase in depressive symptoms compared to matched controls. There was a further increase in depressive symptoms in stroke survivors after the acute event, which persisted for several years. Symptom-level analyses revealed that differences in depressive symptoms between stroke survivors and stroke-free controls before and after stroke were most pronounced for mood- and fatigue-related symptoms. Discussion: Incident stroke is associated with long-term increases in depressive symptoms. A small part of this increase occurs in the years before stroke, perhaps indicating the incipient pathological process. Particular attention should be paid to depressive symptoms in the long-term care of patients, and especially to fatigue-related symptoms.

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Language(s): eng - English
 Dates: 2021-06-112022-04-052022-07-132022-08-16
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1212/WNL.0000000000200756
Other: online ahead of print
PMID: 35831179
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Title: Neurology
Source Genre: Journal
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Publ. Info: Cleveland, Ohio [etc.] : Advanstar Communications [etc.]
Pages: - Volume / Issue: 99 (7) Sequence Number: - Start / End Page: e720 - e729 Identifier: ISSN: 0028-3878
CoNE: https://pure.mpg.de/cone/journals/resource/954925246073