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  Abnormal brain iron accumulation in obstructive sleep apnea: A quantitative MRI study in the HypnoLaus cohort

Marchi, N. A., Pizzarotti, B., Solelhac, G., Berger, M., Haba‐Rubio, J., Preisig, M., et al. (2022). Abnormal brain iron accumulation in obstructive sleep apnea: A quantitative MRI study in the HypnoLaus cohort. Journal of Sleep Research, 31(6): e13698. doi:10.1111/jsr.13698.

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 Creators:
Marchi, Nicola Andrea1, 2, Author
Pizzarotti, Beatrice2, Author
Solelhac, Geoffroy1, Author
Berger, Mathieu1, Author
Haba‐Rubio, José1, Author
Preisig, Martin3, Author
Vollenweider, Peter4, Author
Marques‐Vidal, Pedro4, Author
Lutti, Antoine2, Author
Kherif, Ferath2, Author
Heinzer, Raphael1, Author
Draganski, Bogdan2, 5, Author           
Affiliations:
1Centre for Investigation and Research on Sleep, Centre hospitalier universitaire vaudois, Lausanne, Switzerland, ou_persistent22              
2Département des Neurosciences Cliniques, Laboratoire de Recherche en Neuroimagerie (LREN), Centre hospitalier universitaire vaudois, Lausanne, Switzerland, ou_persistent22              
3Department of Psychiatry, Centre hospitalier universitaire vaudois, Lausanne, Switzerland, ou_persistent22              
4Department of Medicine, Centre hospitalier universitaire vaudois, Lausanne, Switzerland, ou_persistent22              
5Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              

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Free keywords: Alzheimer's disease; R2*; Ageing; Neurodegeneration; Sleep-disordered breathing
 Abstract: Obstructive sleep apnea syndrome (OSA) may be a risk factor for Alzheimer's disease. One of the hallmarks of Alzheimer's disease is disturbed iron homeostasis leading to abnormal iron deposition in brain tissue. To date, there is no empirical evidence to support the hypothesis of altered brain iron homeostasis in patients with obstructive sleep apnea as well. Data were analysed from 773 participants in the HypnoLaus study (mean age 55.9 ± 10.3 years) who underwent polysomnography and brain MRI. Cross-sectional associations were tested between OSA parameters and the MRI effective transverse relaxation rate (R2*) - indicative of iron content - in 68 grey matter regions, after adjustment for confounders. The group with severe OSA (apnea-hypopnea index ≥30/h) had higher iron levels in the left superior frontal gyrus (F3,760 = 4.79, p = 0.003), left orbital gyri (F3,760 = 5.13, p = 0.002), right and left middle temporal gyrus (F3,760 = 4.41, p = 0.004 and F3,760 = 13.08, p < 0.001, respectively), left angular gyrus (F3,760 = 6.29, p = 0.001), left supramarginal gyrus (F3,760 = 4.98, p = 0.003), and right cuneus (F3,760 = 7.09, p < 0.001). The parameters of nocturnal hypoxaemia were all consistently associated with higher iron levels. Measures of sleep fragmentation had less consistent associations with iron content. This study provides the first evidence of increased brain iron levels in obstructive sleep apnea. The observed iron changes could reflect underlying neuropathological processes that appear to be driven primarily by hypoxaemic mechanisms.

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Language(s): eng - English
 Dates: 2022-07-132022-12
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1111/jsr.13698
Other: epub 2022
PMID: 35830960
 Degree: -

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Title: Journal of Sleep Research
Source Genre: Journal
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Publ. Info: Oxford : Published on behalf of the European Sleep Research Society by Blackwell Scientific Publications
Pages: - Volume / Issue: 31 (6) Sequence Number: e13698 Start / End Page: - Identifier: ISSN: 0962-1105
CoNE: https://pure.mpg.de/cone/journals/resource/954925580121