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  Association of Clonal Hematopoiesis of Indeterminate Potential with Inflammatory Gene Expression in Patients with COPD

Kuhnert, S., Mansouri, S., Rieger, M. A., Savai, R., Avci, E., Diaz-Pina, G., et al. (2022). Association of Clonal Hematopoiesis of Indeterminate Potential with Inflammatory Gene Expression in Patients with COPD. CELLS, 11(13): 2121. doi:10.3390/cells11132121.

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 Creators:
Kuhnert, Stefan, Author
Mansouri, Siavash1, Author           
Rieger, Michael A., Author
Savai, Rajkumar1, Author           
Avci, Edibe1, Author           
Diaz-Pina, Gabriela1, Author           
Padmasekar, Manju1, Author           
Looso, Mario2, Author           
Hadzic, Stefan, Author
Acker, Till, Author
Klatt, Stephan, Author
Wilhelm, Jochen1, Author           
Fleming, Ingrid, Author
Sommer, Natascha, Author
Weissmann, Norbert, Author
Vogelmeier, Claus, Author
Bals, Robert, Author
Zeiher, Andreas, Author
Dimmeler, Stefanie, Author
Seeger, Werner1, Author           
Pullamsetti, Soni S.1, Author            more..
Affiliations:
1Lung Development and Remodeling, Max Planck Institute for Heart and Lung Research, Max Planck Society, ou_2591698              
2Bioinformatics, Max Planck Institute for Heart and Lung Research, Max Planck Society, ou_2591704              

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 Abstract: Chronic obstructive pulmonary disease (COPD) is a disease with an inflammatory phenotype with increasing prevalence in the elderly. Expanded population of mutant blood cells carrying somatic mutations is termed clonal hematopoiesis of indeterminate potential (CHIP). The association between CHIP and COPD and its relevant effects on DNA methylation in aging are mainly unknown. Analyzing the deep-targeted amplicon sequencing from 125 COPD patients, we found enhanced incidence of CHIP mutations (similar to 20%) with a predominance of DNMT3A CHIP-mediated hypomethylation of Phospholipase D Family Member 5 (PLD5), which in turn is positively correlated with increased levels of glycerol phosphocholine, pro-inflammatory cytokines, and deteriorating lung function.

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 Dates: 2022-07-05
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000822111000001
DOI: 10.3390/cells11132121
PMID: 35805204
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Title: CELLS
Source Genre: Journal
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Pages: - Volume / Issue: 11 (13) Sequence Number: 2121 Start / End Page: - Identifier: -