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  Association of Clonal Hematopoiesis of Indeterminate Potential with Inflammatory Gene Expression in Patients with COPD

Kuhnert, S., Mansouri, S., Rieger, M. A., Savai, R., Avci, E., Diaz-Pina, G., et al. (2022). Association of Clonal Hematopoiesis of Indeterminate Potential with Inflammatory Gene Expression in Patients with COPD. CELLS, 11(13): 2121. doi:10.3390/cells11132121.

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Kuhnert, Stefan, Autor
Mansouri, Siavash1, Autor           
Rieger, Michael A., Autor
Savai, Rajkumar1, Autor           
Avci, Edibe1, Autor           
Diaz-Pina, Gabriela1, Autor           
Padmasekar, Manju1, Autor           
Looso, Mario2, Autor           
Hadzic, Stefan, Autor
Acker, Till, Autor
Klatt, Stephan, Autor
Wilhelm, Jochen1, Autor           
Fleming, Ingrid, Autor
Sommer, Natascha, Autor
Weissmann, Norbert, Autor
Vogelmeier, Claus, Autor
Bals, Robert, Autor
Zeiher, Andreas, Autor
Dimmeler, Stefanie, Autor
Seeger, Werner1, Autor           
Pullamsetti, Soni S.1, Autor            mehr..
Affiliations:
1Lung Development and Remodeling, Max Planck Institute for Heart and Lung Research, Max Planck Society, ou_2591698              
2Bioinformatics, Max Planck Institute for Heart and Lung Research, Max Planck Society, ou_2591704              

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 Zusammenfassung: Chronic obstructive pulmonary disease (COPD) is a disease with an inflammatory phenotype with increasing prevalence in the elderly. Expanded population of mutant blood cells carrying somatic mutations is termed clonal hematopoiesis of indeterminate potential (CHIP). The association between CHIP and COPD and its relevant effects on DNA methylation in aging are mainly unknown. Analyzing the deep-targeted amplicon sequencing from 125 COPD patients, we found enhanced incidence of CHIP mutations (similar to 20%) with a predominance of DNMT3A CHIP-mediated hypomethylation of Phospholipase D Family Member 5 (PLD5), which in turn is positively correlated with increased levels of glycerol phosphocholine, pro-inflammatory cytokines, and deteriorating lung function.

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 Datum: 2022-07-05
 Publikationsstatus: Online veröffentlicht
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 Identifikatoren: ISI: 000822111000001
DOI: 10.3390/cells11132121
PMID: 35805204
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Titel: CELLS
Genre der Quelle: Zeitschrift
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Seiten: - Band / Heft: 11 (13) Artikelnummer: 2121 Start- / Endseite: - Identifikator: -