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  In Situ Ternary Adduct Formation of Yttrium Polyaminocarboxylates Leads to Small Molecule Capture and Activation

Tickner, B., Platas-Iglesias, C., Duckett, S., & Angelovski, G. (2022). In Situ Ternary Adduct Formation of Yttrium Polyaminocarboxylates Leads to Small Molecule Capture and Activation. Chemistry – A European Journal, Epub ahead. doi:10.1002/chem.202201780.

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Tickner, BJ, Author
Platas-Iglesias, C, Author
Duckett, SB, Author
Angelovski, G1, Author           
Affiliations:
1Research Group MR Neuroimaging Agents, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528691              

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 Abstract: In this work we exploit the chemistry of yttrium complexes for small molecule capture and activation. Nuclear magnetic resonance (NMR) and density functional theory (DFT) studies were used to investigate the in situ formation of solution state ternary yttrium-acetate, yttrium-bicarbonate, and yttrium-pyruvate adducts with a range of polyaminocarboxylate chelates. These studies reveal that [Y(DO3A)(H 2 O) 2 ] (H 3 DO3A − 1,4,7,10-tetraazacyclododecane-1,4,7-tricarboxylic acid) and [Y(EDTA)(H 2 O) 2 ] - (H 4 EDTA − ethylenediaminetetraacetic acid) are able to form ternary adducts with bicarbonate and pyruvate. In the latter, unusual decarboxylation of pyruvate to form acetic acid and CO 2 was observed and further studied using SABRE-hyperpolarised 13 C NMR (SABRE − signal amplification by reversible exchange) to provide information about the reaction timescale and lifetime of intermediates involved in this conversion. The work presented demonstrates that yttrium complexes can capture and activate small molecules, which may lead to novel and useful applications of this metal in catalysis and medical imaging.

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 Dates: 2022-09
 Publication Status: Published online
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 Rev. Type: -
 Identifiers: DOI: 10.1002/chem.202201780
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Title: Chemistry – A European Journal
  Other : Chem. – Eur. J.
  Other : Chem. Eur. J.
Source Genre: Journal
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Publ. Info: Weinheim : Wiley-VCH
Pages: - Volume / Issue: Epub ahead Sequence Number: - Start / End Page: - Identifier: ISSN: 0947-6539
CoNE: https://pure.mpg.de/cone/journals/resource/954926979058