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  7T functional MRI finds no evidence for distinct functional subregions in the subthalamic nucleus during a speeded decision-making task

Miletić, S., Keuken, M. C., Mulder, M., Trampel, R., de Hollander, G., & Forstmann, B. U. (2022). 7T functional MRI finds no evidence for distinct functional subregions in the subthalamic nucleus during a speeded decision-making task. Cortex, 155, 162-188. doi:10.1016/j.cortex.2022.06.014.

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 Creators:
Miletić, Steven1, Author
Keuken, Max C.1, Author
Mulder, Martijn2, Author
Trampel, Robert3, Author           
de Hollander, Gilles4, Author
Forstmann, Birte U.1, Author
Affiliations:
1Department of Psychology, University of Amsterdam, the Netherlands, ou_persistent22              
2Department of Psychology, Utrecht University, the Netherlands, ou_persistent22              
3Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              
4Department of Economics, University of Zurich, Switzerland, ou_persistent22              

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Free keywords: Subthalamic nucleus; Tripartite model; Decision making; Model-based cognitive neuroscience
 Abstract: The subthalamic nucleus (STN) is a small, subcortical brain structure. It is a target for deep brain stimulation, an invasive treatment that reduces motor symptoms of Parkinson’s disease. Side effects of DBS are commonly explained using the tripartite model of STN organization, which proposes three functionally distinct subregions in the STN specialized in cognitive, limbic, and motor processing. However, evidence for the tripartite model exclusively comes from anatomical studies and functional studies using clinical patients. Here, we provide the first experimental tests of the tripartite model in healthy volunteers using ultra-high field 7 Tesla (T) functional magnetic resonance imaging (fMRI). Thirty-four participants performed a random-dot motion decision-making task with a difficulty manipulation and a choice payoff manipulation aimed to differentially affect cognitive and limbic networks. Moreover, participants responded with their left and right index finger, differentially affecting motor networks. We analysed BOLD signal in three subregions of the STN along the dorsolateral-ventromedial axis, identified using manually delineated high resolution anatomical images and based on a previously published atlas. Using these paradigms, all segments responded equally to the experimental manipulations, and the tasks did not provide evidence for the tripartite model.

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Language(s): eng - English
 Dates: 2022-03-182021-08-302022-06-072022-07-162022-10
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/j.cortex.2022.06.014
Other: online ahead of print
PMID: 35994782
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Project name : -
Grant ID : 313481
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Funding organization : European Research Council
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Grant ID : 016.Vici.185.052
Funding program : -
Funding organization : NWO-VICI

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Title: Cortex
  Other : Cortex
Source Genre: Journal
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Publ. Info: Milan [etc.] : Elsevier Masson SAS
Pages: - Volume / Issue: 155 Sequence Number: - Start / End Page: 162 - 188 Identifier: ISSN: 0010-9452
CoNE: https://pure.mpg.de/cone/journals/resource/954925393344