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  Awake Mouse fMRI and Pupillary Recordings in the Ultra-High Magnetic Field

Zeng, H., Jiang, Y., Beer-Hammer, S., & Yu, X. (2022). Awake Mouse fMRI and Pupillary Recordings in the Ultra-High Magnetic Field. Frontiers in Neuroscience, 16: 886709. doi:10.3389/fnins.2022.886709.

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Zeng, H1, Autor           
Jiang, Y, Autor           
Beer-Hammer, S, Autor
Yu, X, Autor           
Affiliations:
1Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528695              

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 Zusammenfassung: Awake rodent fMRI is becoming a promising non-invasive brain imaging module when investigating large-scale brain function given behavioral tasks. Previous studies have either applied sedatives during scanning or pre-treatment of anesthetics, e.g., isoflurane, to reduce the motion of animals, which could confound the brain function of "awake" states in rodents. Here, we have established a long training awake mouse fMRI-pupillometry paradigm/setup without the initial use of anesthesia. To validate the awake mouse fMRI platform, evoked BOLD-fMRI was performed to identify brain activation in the visual cortex, dorsal lateral geniculate nuclei, and superior colliculus. Furthermore, pupil signal fluctuation was investigated during scanning, showing a less dilated pupil after 5-8 weeks of intermittent training. Thus, using the awake mouse fMRI with real-time pupillometry provides a longitudinal functional mapping tool to study fully conscious mice.

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 Datum: 2022-07
 Publikationsstatus: Online veröffentlicht
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 Identifikatoren: DOI: 10.3389/fnins.2022.886709
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Titel: Frontiers in Neuroscience
  Andere : Front Neurosci
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: Lausanne, Switzerland : Frontiers Research Foundation
Seiten: 9 Band / Heft: 16 Artikelnummer: 886709 Start- / Endseite: - Identifikator: ISSN: 1662-4548
ISSN: 1662-453X
CoNE: https://pure.mpg.de/cone/journals/resource/1662-4548