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  Awake Mouse fMRI and Pupillary Recordings in the Ultra-High Magnetic Field

Zeng, H., Jiang, Y., Beer-Hammer, S., & Yu, X. (2022). Awake Mouse fMRI and Pupillary Recordings in the Ultra-High Magnetic Field. Frontiers in Neuroscience, 16: 886709. doi:10.3389/fnins.2022.886709.

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Zeng, H1, Author           
Jiang, Y, Author           
Beer-Hammer, S, Author
Yu, X, Author           
Affiliations:
1Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528695              

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 Abstract: Awake rodent fMRI is becoming a promising non-invasive brain imaging module when investigating large-scale brain function given behavioral tasks. Previous studies have either applied sedatives during scanning or pre-treatment of anesthetics, e.g., isoflurane, to reduce the motion of animals, which could confound the brain function of "awake" states in rodents. Here, we have established a long training awake mouse fMRI-pupillometry paradigm/setup without the initial use of anesthesia. To validate the awake mouse fMRI platform, evoked BOLD-fMRI was performed to identify brain activation in the visual cortex, dorsal lateral geniculate nuclei, and superior colliculus. Furthermore, pupil signal fluctuation was investigated during scanning, showing a less dilated pupil after 5-8 weeks of intermittent training. Thus, using the awake mouse fMRI with real-time pupillometry provides a longitudinal functional mapping tool to study fully conscious mice.

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 Dates: 2022-07
 Publication Status: Published online
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 Identifiers: DOI: 10.3389/fnins.2022.886709
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Title: Frontiers in Neuroscience
  Other : Front Neurosci
Source Genre: Journal
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Publ. Info: Lausanne, Switzerland : Frontiers Research Foundation
Pages: 9 Volume / Issue: 16 Sequence Number: 886709 Start / End Page: - Identifier: ISSN: 1662-4548
ISSN: 1662-453X
CoNE: https://pure.mpg.de/cone/journals/resource/1662-4548