Gene losses in the common vampire bat illuminate molecular adaptations to blood 
feeding

Blumer , Moritz; Brown, Tom; Freitas, Mariella Bontempo; Destro, Ana Luiza; Oliveira, Juraci A.; Morales, Ariadna E.; Schell, Tilman; Greve, Carola; Pippel, Martin; Jebb, David; Hecker, Nikolai; Ahmed, Alexis-Walid; Kirilenko, Bogdan M.; Foote, Maddy; Janke, Axel; Lim, Burton K.; Hiller, Michael

doi:10.1126/sciadv.abm6494

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Gene losses in the common vampire bat illuminate molecular adaptations to blood feeding

Blumer, M., Brown, T., Freitas, M. B., Destro, A. L., Oliveira, J. A., Morales, A. E., et al. (2022). Gene losses in the common vampire bat illuminate molecular adaptations to blood feeding. Science Advances, 8(12): eabm6494. doi:10.1126/sciadv.abm6494.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000A-CF9B-F Version Permalink: https://hdl.handle.net/21.11116/0000-000A-CF9C-E

Genre: Journal Article

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Creators:
Blumer , Moritz¹, Author
Brown, Tom¹, Author
Freitas, Mariella Bontempo¹, Author
Destro, Ana Luiza¹, Author
Oliveira, Juraci A.¹, Author
Morales, Ariadna E.¹, Author
Schell, Tilman¹, Author
Greve, Carola¹, Author
Pippel, Martin¹, Author
Jebb, David², Author
Hecker, Nikolai², Author
Ahmed, Alexis-Walid¹, Author
Kirilenko, Bogdan M.¹, Author
Foote, Maddy¹, Author
Janke, Axel¹, Author
Lim, Burton K.¹, Author
Hiller, Michael², Author

Affiliations:
1external, ou_persistent22
2Max Planck Institute for the Physics of Complex Systems, Max Planck Society, ou_2117288

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Abstract: Vampire bats are the only mammals that feed exclusively on blood. To uncover genomic changes associated with this dietary adaptation, we generated a haplotype-resolved genome of the common vampire bat and screened 27 bat species for genes that were specifically lost in the vampire bat lineage. We found previously unknown gene losses that relate to reduced insulin secretion (FFAR1 and SLC30A8), limited glycogen stores (PPP1R3E), and a unique gastric physiology (CTSE). Other gene losses likely reflect the biased nutrient composition (ERN2 and CTRL) and distinct pathogen diversity of blood (RNASE7) and predict the complete lack of cone-based vision in these strictly nocturnal bats (PDE6H and PDE6C). Notably, REP15 loss likely helped vampire bats adapt to high dietary iron levels by enhancing iron excretion, and the loss of CYP39A1 could have contributed to their exceptional cognitive abilities. These findings enhance our understanding of vampire bat biology and the genomic underpinnings of adaptations to blood feeding.

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Language(s): eng - English

Dates: Published Online: 2022-03-25Date issued: 2022-03-25

Publication Status: Issued

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Identifiers: ISI: 000800334900016
DOI: 10.1126/sciadv.abm6494

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Title: Science Advances

Other : Sci. Adv.

Source Genre: Journal

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Publ. Info: Washington : AAAS

Pages: - Volume / Issue: 8 (12) Sequence Number: eabm6494 Start / End Page: - Identifier: ISSN: 2375-2548
CoNE: https://pure.mpg.de/cone/journals/resource/2375-2548