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  A field‐independent method for the rapid generation of hyperpolarized [1‐13C]Pyruvate in clean water solutions for biomedical applications

Mamone, S., Jagtap, A. P., Korchak, S., Ding, Y., Sternkopf, S., & Glöggler, S. (2022). A field‐independent method for the rapid generation of hyperpolarized [1‐13C]Pyruvate in clean water solutions for biomedical applications. Angewandte Chemie, e202206298. doi:10.1002/ange.202206298.

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Genre: Journal Article

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3398240.pdf (Publisher version), 3MB
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 Creators:
Mamone, S.1, Author           
Jagtap, A. P.1, Author           
Korchak, S.1, Author           
Ding, Y.1, Author           
Sternkopf, S.1, Author           
Glöggler, S.1, Author           
Affiliations:
1Research Group of NMR Signal Enhancement, Max Planck Institute for Multidisciplinary Sciences, Max Planck Society, ou_3350277              

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Free keywords: Hyperpolarization; Magnetic Resonance; metabolic Probes; Para-Hydrogen; Pyruvate
 Abstract: Hyperpolarization methods in magnetic resonance enhance the signals by several orders of magnitude, opening new windows for real-time investigations of dynamic processes in vitro and in vivo. Here, we propose a field-independent para-hydrogen-based pulsed method to produce rapidly hyperpolarized 13C-labeled substrates. We demonstrate the method by polarizing the carboxylic carbon of the pyruvate moiety in a purposely designed precursor to 24 % at ≈22 mT. Following a fast purification procedure, we measure 8 % polarization on free [1-13C]pyruvate in clean water solutions at physiological conditions at 7 T. The enhanced signals allow real-time monitoring of the pyruvate-lactate conversion in cancer cells, demonstrating the potential of the method for biomedical applications in combination with existing or developing magnetic resonance technologies.

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Language(s): eng - English
 Dates: 2022-06-20
 Publication Status: Published online
 Pages: 6
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1002/ange.202206298
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Project name : S. G. thanks the Deutsche Forschungs- gemeinschaft (DFG) for funding (grants 418416679, 426677227 and 450146057). This project has received fund- ing from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovationprogram (Grant agreement No. 949180).
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Project name : HyperULFNMR
Grant ID : 949180
Funding program : Horizon 2020 (H2020)
Funding organization : European Commission (EC)

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Title: Angewandte Chemie
Source Genre: Journal
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Pages: 6 Volume / Issue: - Sequence Number: e202206298 Start / End Page: - Identifier: ISSN: 0044-8249
ISSN: 1521-3757