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  Regulation of social hierarchy learning by serotonin transporter availability

Janet, R., Ligneul, R., Losecaat-Vermeer, A., Philippe, R., Bellucci, G., Derrington, E., et al. (2022). Regulation of social hierarchy learning by serotonin transporter availability. Neuropsychopharmacology, Epub ahead. doi:10.1038/s41386-022-01378-2.

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Janet, R, Author
Ligneul, R, Author
Losecaat-Vermeer, AB, Author
Philippe, R, Author
Bellucci, G1, Author           
Derrington, E, Author
Park, SQ, Author
Dreher, J-C, Author
Affiliations:
1Department of Computational Neuroscience, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_3017468              

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 Abstract: Learning one's status in a group is a fundamental process in building social hierarchies. Although animal studies suggest that serotonin (5-HT) signaling modulates learning social hierarchies, direct evidence in humans is lacking. Here we determined the relationship between serotonin transporter (SERT) availability and brain systems engaged in learning social ranks combining computational approaches with simultaneous PET-fMRI acquisition in healthy males. We also investigated the link between SERT availability and brain activity in a non-social control condition involving learning the payoffs of slot machines. Learning social ranks was modulated by the dorsal raphe nucleus (DRN) 5-HT function. BOLD ventral striatal response, tracking the rank of opponents, decreased with DRN SERT levels. Moreover, this link was specific to the social learning task. These findings demonstrate that 5-HT plays an influence on the computations required to learn social ranks.

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 Dates: 2022-08
 Publication Status: Published online
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 Identifiers: DOI: 10.1038/s41386-022-01378-2
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Title: Neuropsychopharmacology
  Other : Neuropsychopharmacology: off. publ. of the American College of Neuropsychopharmacology
  Abbreviation : Neuropsychopharmacol
Source Genre: Journal
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Publ. Info: New York, NY : Springer Nature
Pages: - Volume / Issue: Epub ahead Sequence Number: - Start / End Page: - Identifier: ISSN: 0893-133X
CoNE: https://pure.mpg.de/cone/journals/resource/954925558485