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  Social determinants and lifestyle factors for brain health: Implications for risk reduction of cognitive decline and dementia

Röhr, S., Pabst, A., Baber, R., Engel, C., Glaesmer, H., Hinz, A., et al. (2022). Social determinants and lifestyle factors for brain health: Implications for risk reduction of cognitive decline and dementia. Scientific Reports, 12(1): 12965. doi:10.1038/s41598-022-16771-6.

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 Creators:
Röhr, Susanne1, 2, Author
Pabst, Alexander1, Author
Baber, Ronny3, 4, Author
Engel, Christoph4, 5, Author
Glaesmer, Heide6, Author
Hinz, Andreas6, Author
Schroeter, Matthias L.7, 8, Author           
Witte, A. Veronica, Author           
Zeynalova, Samira4, 5, Author
Villringer, Arno7, 8, Author           
Löffler, Markus4, 5, Author
Riedel-Heller, Steffi G.1, Author
Affiliations:
1Institute of Social Medicine, Occupational Health and Public Health (ISAP), University Hospital Leipzig, Germany, ou_persistent22              
2Global Brain Health Institute (GBHI), Trinity College Dublin, Ireland, ou_persistent22              
3Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics (ILM), University of Leipzig, Germany, ou_persistent22              
4Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, Germany, ou_persistent22              
5Institute for Medical Informatics, Statistics and Epidemiology (IMISE), University of Leipzig, Germany, ou_persistent22              
6Department of Medical Psychology and Medical Sociology, University of Leipzig, Germany, ou_persistent22              
7Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634549              
8Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              

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Free keywords: Psychology; Risk factors
 Abstract: Substantial evidence indicates a huge potential for risk reduction of cognitive decline and dementia based on modifiable health and lifestyle factors. To maximize the chances for risk reduction, it is useful to investigate associations of social determinants and lifestyle for brain health. We computed the “LIfestyle for BRAin health” (LIBRA) score for baseline participants of the Leipzig Research Centre for Civilization Diseases (LIFE) Adult Study, a population-based urban cohort in Germany. LIBRA predicts dementia in midlife and early late life populations, comprising 12 modifiable risk factors (heart disease, kidney disease, diabetes, obesity, hypertension, hypercholesterolemia, alcohol consumption, smoking, physical inactivity, diet, depression, cognitive inactivity). Associations of social determinants (living situation, marital status, social isolation, education, net equivalence income, occupational status, socioeconomic status/SES, employment) with LIBRA were inspected using age- and sex-adjusted multivariable linear regression analysis. Z-standardization and sampling weights were applied. Participants (n = 6203) were M = 57.4 (SD = 10.6, range 40–79) years old and without dementia, 53.0% were women. Except for marital status, all considered social determinants were significantly associated with LIBRA. Beta coefficients for the association with higher LIBRA scores were most pronounced for low SES (β = 0.80, 95% CI [0.72–0.88]; p < 0.001) and middle SES (β = 0.55, 95% CI [0.47–0.62]; p < 0.001). Social determinants, particularly socioeconomic factors, are associated with lifestyle for brain health, and should thus be addressed in risk reduction strategies for cognitive decline and dementia. A social-ecological public health perspective on risk reduction might be more effective and equitable than focusing on individual lifestyle behaviors alone.

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Language(s): eng - English
 Dates: 2022-03-252022-07-152022-07-28
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1038/s41598-022-16771-6
PMID: 35902604
PMC: PMC9334303
 Degree: -

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Title: Scientific Reports
  Abbreviation : Sci. Rep.
Source Genre: Journal
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Publ. Info: London, UK : Nature Publishing Group
Pages: - Volume / Issue: 12 (1) Sequence Number: 12965 Start / End Page: - Identifier: ISSN: 2045-2322
CoNE: https://pure.mpg.de/cone/journals/resource/2045-2322