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  Association between self-rating depression scores and total ghrelin and adipokine serum levels in a large population-based sample

Wittekind, D. A., Kratzsch, J., Biemann, R., Mergl, R., Riedel-Heller, S., Witte, A. V., et al. (2022). Association between self-rating depression scores and total ghrelin and adipokine serum levels in a large population-based sample. Frontiers in Psychiatry, 13: 891325. doi:10.3389/fpsyt.2022.891325.

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 Creators:
Wittekind, Dirk Alexander1, Author
Kratzsch, Jürgen2, Author
Biemann, Ronald2, Author
Mergl, Ronald3, Author
Riedel-Heller, Steffi4, Author
Witte, A. Veronica5, Author           
Villringer, Arno5, Author           
Kluge, Michael1, Author
Affiliations:
1Department of Psychiatry and Psychotherapy, University Hospital Leipzig, Germany, ou_persistent22              
2Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics (ILM), University of Leipzig, Germany, ou_persistent22              
3Institute of Psychology, Bundeswehr University Munich, Germany, ou_persistent22              
4Faculty of Medicine, Institute of Social Medicine, Occupational Health and Public Health, University of Leipzig, Leipzig, Germany, ou_persistent22              
5Institute of Social Medicine, Occupational Health and Public Health (ISAP), University Hospital Leipzig, Germany, ou_persistent22              

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Free keywords: Adiponectin; CES-D; Depression; Ghrelin; IDS-SR; Leptin
 Abstract: Background: Ghrelin and the adipokines leptin and adiponectin have been suggested to be involved in mood and anxiety regulation and to be altered in affective disorders. However, studies investigating the association between ghrelin, leptin and adiponectin and depressive symptomatology are scarce but might contribute to a better understanding of their involvement in mood regulation. We thus aimed investigating the association between depressive symptomatology and total ghrelin as well as leptin and adiponectin serum levels in a large population-based sample. Methods: Total serum ghrelin, adiponectin and leptin levels were determined in 1666 subjects of a population-based cross-sectional study (“LIFE”). The Center for Epidemiological Studies Depression Scale (CES-D) and the Inventory of Depressive Symptoms – Self Rating (IDS-SR) were administered. Multiple linear regression analyses were conducted to examine the association between total serum ghrelin, leptin and adiponectin and the intensity of depressive symptoms. Results: In the total sample (n = 1,092), neither ghrelin nor leptin or adiponectin serum levels showed a significant association with CES-D or IDS-SR sum scores (N = 1,092) or in depressed/non-depressed subjects. Leptin serum levels showed a significantly positive association with IDS-SR sum scores in elderly men (≥60 years; β = 0.122, 95% CI: 0.009; 0.236; p = 0.035). Conclusion: Our study suggests that peripheral levels of ghrelin and adipokines in a cross-sectional study design might not be sufficient to measure their involvement in depression, suggesting that associations are more complex and multi-layered. Copyright © 2022 Wittekind, Kratzsch, Biemann, Mergl, Riedel-Heller, Witte, Villringer and Kluge.

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Language(s): eng - English
 Dates: 2022-03-082022-04-142022-05-11
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.3389/fpsyt.2022.891325
Other: eCollection 2022
PMID: 35633817
PMC: PMC9130496
 Degree: -

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Title: Frontiers in Psychiatry
  Abbreviation : Front Psychiatry
Source Genre: Journal
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Publ. Info: Lausanne, Switzerland : Frontiers Research Foundation
Pages: - Volume / Issue: 13 Sequence Number: 891325 Start / End Page: - Identifier: ISSN: 1664-0640
CoNE: https://pure.mpg.de/cone/journals/resource/16640640