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  Detailed stratified GWAS analysis for severe COVID-19 in four European populations

Degenhardt, F., Ellinghaus, D., Juzenas, S., Lerga-Jaso, J., Wendorff, M., Maya-Miles, D., et al. (2022). Detailed stratified GWAS analysis for severe COVID-19 in four European populations. Human Molecular Genetics, 31(23), 3945-3966. doi:10.1093/hmg/ddac158.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000C-DC84-7 Version Permalink: https://hdl.handle.net/21.11116/0000-000C-DC85-6
Genre: Journal Article

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 Creators:
Degenhardt, Frauke1, Author
Ellinghaus, David1, Author
Juzenas, Simonas1, Author
Lerga-Jaso, Jon1, Author
Wendorff, Mareike1, Author
Maya-Miles, Douglas1, Author
Uellendahl-Werth, Florian1, Author
El Abd, Hesham2, Author           
Rühlemann, Malte C1, Author
Arora, Jatin1, Author           
Özer, Onur2, Author           
Lenning, Ole Bernt1, Author
Myhre, Ronny1, Author
Vadla, May Sissel1, Author
Wacker, Eike M1, Author
Wienbrandt, Lars1, Author
Ortiz, Aaron Blandino1, Author
Salazar, Adolfo1, Author
Chercoles, Adolfo Garrido1, Author
Palom, Adriana1, Author
Ruiz, Agustín1, AuthorGarcia-Fernandez, Alba-Estela1, AuthorBlanco-Grau, Albert1, AuthorMantovani, Alberto1, AuthorZanella, Alberto1, AuthorHolten, Aleksander Rygh1, AuthorMayer, Alena1, AuthorBandera, Alessandra1, AuthorCherubini, Alessandro1, AuthorProtti, Alessandro1, AuthorAghemo, Alessio1, AuthorGerussi, Alessio1, AuthorRamirez, Alfredo1, AuthorBraun, Alice1, AuthorNebel, Almut1, AuthorBarreira, Ana1, AuthorLleo, Ana1, AuthorTeles, Ana1, AuthorKildal, Anders Benjamin1, AuthorBiondi, Andrea1, AuthorCaballero-Garralda, Andrea1, AuthorGanna, Andrea1, AuthorGori, Andrea1, AuthorGlück, Andreas1, AuthorLind, Andreas1, AuthorTanck, Anja1, AuthorHinney, Anke1, AuthorNolla, Anna Carreras1, AuthorFracanzani, Anna Ludovica1, AuthorPeschuck, Anna1, AuthorCavallero, Annalisa1, AuthorDyrhol-Riise, Anne Ma1, AuthorRuello, Antonella1, AuthorJulià, Antonio1, AuthorMuscatello, Antonio1, AuthorPesenti, Antonio1, AuthorVoza, Antonio1, AuthorRando-Segura, Ariadna1, AuthorSolier, Aurora1, AuthorSchmidt, Axel1, AuthorCortes, Beatriz1, AuthorMateos, Beatriz1, AuthorNafria-Jimenez, Beatriz1, AuthorSchaefer, Benedikt1, AuthorJensen, Björn1, AuthorBellinghausen, Carla1, AuthorMaj, Carlo1, AuthorFerrando, Carlos1, AuthorHorra, Carmen1, AuthorQuereda, Carmen1, AuthorSkurk, Carsten1, AuthorThibeault, Charlotte1, AuthorScollo, Chiara1, AuthorHerr, Christian1, AuthorSpinner, Christoph D1, AuthorGassner, Christoph1, AuthorLange, Christoph1, AuthorHu, Cinzia1, AuthorPaccapelo, Cinzia1, AuthorLehmann, Clara1, AuthorAngelini, Claudio1, AuthorCappadona, Claudio1, AuthorAzuure, Clinton1, AuthorBianco, Cristiana1, AuthorCea, Cristina1, AuthorSancho, Cristina1, AuthorHoff, Dag Arne Lihaug1, AuthorGalimberti, Daniela1, AuthorPrati, Daniele1, AuthorHaschka, David1, AuthorJiménez, David1, AuthorPestaña, David1, AuthorToapanta, David1, AuthorMuñiz-Diaz, Eduardo1, AuthorAzzolini, Elena1, AuthorSandoval, Elena1, AuthorBinatti, Eleonora1, AuthorScarpini, Elio1, AuthorHelbig, Elisa T1, AuthorCasalone, Elisabetta1, AuthorUrrechaga, Eloisa1, AuthorParaboschi, Elvezia Maria1, AuthorPontali, Emanuele1, AuthorReverter, Enric1, AuthorCalderón, Enrique J1, AuthorNavas, Enrique1, AuthorSolligård, Erik1, AuthorContro, Ernesto1, AuthorArana-Arri, Eunate1, AuthorAziz, Fátima1, AuthorGarcia, Federico1, AuthorSánchez, Félix García1, AuthorCeriotti, Ferruccio1, AuthorMartinelli-Boneschi, Filippo1, AuthorPeyvandi, Flora1, AuthorKurth, Florian1, AuthorBlasi, Francesco1, AuthorMalvestiti, Francesco1, AuthorMedrano, Francisco J1, AuthorMesonero, Francisco1, AuthorRodriguez-Frias, Francisco1, AuthorHanses, Frank1, AuthorMüller, Fredrik1, AuthorHemmrich-Stanisak, Georg1, AuthorBellani, Giacomo1, AuthorGrasselli, Giacomo1, AuthorPezzoli, Gianni1, AuthorCostantino, Giorgio1, AuthorAlbano, Giovanni1, AuthorCardamone, Giulia1, AuthorBellelli, Giuseppe1, AuthorCiterio, Giuseppe1, AuthorFoti, Giuseppe1, AuthorLamorte, Giuseppe1, AuthorMatullo, Giuseppe1, AuthorBaselli, Guido1, AuthorKurihara, Hayato1, AuthorNeb, Holger1, AuthorMy, Ilaria1, AuthorKurth, Ingo1, AuthorHernández, Isabel1, AuthorPink, Isabell1, AuthorRojas, Itziar1, AuthorGalván-Femenia, Iván1, AuthorHolter, Jan Cato1, AuthorAfset, Jan Egil1, AuthorHeyckendorf, Jan1, AuthorKässens, Jan1, AuthorDamås, Jan Kristian1, AuthorRybniker, Jan1, AuthorAltmüller, Janine1, AuthorAmpuero, Javier1, AuthorMartín, Javier1, AuthorErdmann, Jeanette1, AuthorBanales, Jesus M1, AuthorBadia, Joan Ramon1, AuthorDopazo, Joaquin1, AuthorSchneider, Jochen1, AuthorBergan, Jonas1, AuthorBarretina, Jordi1, AuthorWalter, Jörn1, AuthorQuero, Jose Hernández1, AuthorGoikoetxea, Josune1, AuthorDelgado, Juan1, AuthorGuerrero, Juan M1, AuthorFazaal, Julia1, AuthorKraft, Julia1, AuthorSchröder, Julia1, AuthorRisnes, Kari1, AuthorBanasik, Karina1, AuthorMüller, Karl Erik1, AuthorGaede, Karoline I1, AuthorGarcia-Etxebarria, Koldo1, AuthorTonby, Kristian1, AuthorHeggelund, Lars1, AuthorIzquierdo-Sanchez, Laura1, AuthorBettini, Laura Rachele1, AuthorSumoy, Lauro1, AuthorSander, Leif Erik1, AuthorLippert, Lena J1, AuthorTerranova, Leonardo1, AuthorNkambule, Lindokuhle1, AuthorKnopp, Lisa1, AuthorGustad, Lise Tuset1, AuthorGarbarino, Lucia1, AuthorSantoro, Luigi1, AuthorTéllez, Luis1, AuthorRoade, Luisa1, AuthorOstadreza, Mahnoosh1, AuthorIntxausti, Maider1, AuthorKogevinas, Manolis1, AuthorRiveiro-Barciela, Mar1, AuthorBerger, Marc M1, AuthorSchaefer, Marco1, AuthorNiemi, Mari E K1, AuthorGutiérrez-Stampa, María A1, AuthorCarrabba, Maria1, AuthorFiguera Basso, Maria E1, AuthorValsecchi, Maria Grazia1, AuthorHernandez-Tejero, María1, AuthorVehreschild, Maria J G T1, AuthorManunta, Maria1, AuthorAcosta-Herrera, Marialbert1, AuthorD'Angiò, Mariella1, AuthorBaldini, Marina1, AuthorCazzaniga, Marina1, AuthorGrimsrud, Marit M1, AuthorCornberg, Markus1, AuthorNöthen, Markus M1, AuthorMarquié, Marta1, AuthorCastoldi, Massimo1, AuthorCordioli, Mattia1, AuthorCecconi, Maurizio1, AuthorD'Amato, Mauro1, AuthorAugustin, Max1, AuthorTomasi, Melissa1, AuthorBoada, Mercè1, AuthorDreher, Michael1, AuthorSeilmaier, Michael J1, AuthorJoannidis, Michael1, AuthorWittig, Michael1, AuthorMazzocco, Michela1, AuthorCiccarelli, Michele1, AuthorRodríguez-Gandía, Miguel1, AuthorBocciolone, Monica1, AuthorMiozzo, Monica1, AuthorAyo, Natale Imaz1, AuthorBlay, Natalia1, AuthorChueca, Natalia1, AuthorMontano, Nicola1, AuthorBraun, Nicole1, AuthorLudwig, Nicole1, AuthorMarx, Nikolaus1, AuthorMartínez, Nilda1, AuthorCornely, Oliver A1, AuthorWitzke, Oliver1, AuthorPalmieri, Orazio1, AuthorFaverio, Paola1, AuthorPreatoni, Paoletta1, AuthorBonfanti, Paolo1, AuthorOmodei, Paolo1, AuthorTentorio, Paolo1, AuthorCastro, Pedro1, AuthorRodrigues, Pedro M1, AuthorEspaña, Pedro Pablo1, AuthorHoffmann, Per1, AuthorRosenstiel, Philip1, AuthorSchommers, Philipp1, AuthorSuwalski, Phillip1, AuthorPablo, Raúl1, AuthorFerrer, Ricard1, AuthorBals, Robert1, AuthorGualtierotti, Roberta1, AuthorGallego-Durán, Rocío1, AuthorNieto, Rosa1, AuthorCarpani, Rossana1, AuthorMorilla, Rubén1, AuthorBadalamenti, Salvatore1, AuthorHaider, Sammra1, AuthorCiesek, Sandra1, AuthorMay, Sandra1, AuthorBombace, Sara1, AuthorMarsal, Sara1, AuthorPigazzini, Sara1, AuthorKlein, Sebastian1, AuthorPelusi, Serena1, AuthorWilfling, Sibylle1, AuthorBosari, Silvano1, AuthorVolland, Sonja1, AuthorBrunak, Søren1, AuthorRaychaudhuri, Soumya1, AuthorSchreiber, Stefan1, AuthorHeilmann-Heimbach, Stefanie1, AuthorAliberti, Stefano1, AuthorRipke, Stephan1, AuthorDudman, Susanne1, AuthorWesse, Tanja1, AuthorZheng, Tenghao1, AuthorBahmer, Thomas1, AuthorEggermann, Thomas1, AuthorIllig, Thomas1, AuthorBrenner, Thorsten1, AuthorPumarola, Tomas1, AuthorFeldt, Torsten1, AuthorFolseraas, Trine1, AuthorCejudo, Trinidad Gonzalez1, AuthorLandmesser, Ulf1, AuthorProtzer, Ulrike1, AuthorHehr, Ute1, AuthorRimoldi, Valeria1, AuthorMonzani, Valter1, AuthorSkogen, Vegard1, AuthorKeitel, Verena1, AuthorKopfnagel, Verena1, AuthorFriaza, Vicente1, AuthorAndrade, Victor1, AuthorMoreno, Victor1, AuthorAlbrecht, Wolfgang1, AuthorPeter, Wolfgang1, AuthorPoller, Wolfgang1, AuthorFarre, Xavier1, AuthorYi, Xiaoli1, AuthorWang, Xiaomin1, AuthorKhodamoradi, Yascha1, AuthorKaradeniz, Zehra1, AuthorLatiano, Anna1, AuthorGoerg, Siegfried1, AuthorBacher, Petra1, AuthorKoehler, Philipp1, AuthorTran, Florian1, AuthorZoller, Heinz1, AuthorSchulte, Eva C1, AuthorHeidecker, Bettina1, AuthorLudwig, Kerstin U1, AuthorFernández, Javier1, AuthorRomero-Gómez, Manuel1, AuthorAlbillos, Agustín1, AuthorInvernizzi, Pietro1, AuthorButi, Maria1, AuthorDuga, Stefano1, AuthorBujanda, Luis1, AuthorHov, Johannes R1, AuthorLenz, Tobias L.2, Author           Asselta, Rosanna1, AuthorCid, Rafael1, AuthorValenti, Luca1, AuthorKarlsen, Tom H1, AuthorCáceres, Mario1, AuthorFranke, Andre1, Author more..
Affiliations:
1External Organizations, ou_persistent22              
2Emmy Noether Research Group Evolutionary Immunogenomics, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_2616693              

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 Abstract: Given the highly variable clinical phenotype of Coronavirus disease 2019 (COVID-19), a deeper analysis of the host genetic contribution to severe COVID-19 is important to improve our understanding of underlying disease mechanisms. Here, we describe an extended GWAS meta-analysis of a well-characterized cohort of 3255 COVID-19 patients with respiratory failure and 12 488 population controls from Italy, Spain, Norway and Germany/Austria, including stratified analyses based on age, sex and disease severity, as well as targeted analyses of chromosome Y haplotypes, the human leukocyte antigen (HLA) region and the SARS-CoV-2 peptidome. By inversion imputation, we traced a reported association at 17q21.31 to a ~ 0.9-Mb inversion polymorphism that creates two highly differentiated haplotypes and characterized the potential effects of the inversion in detail. Our data, together with the 5th release of summary statistics from the COVID-19 Host Genetics Initiative including non-Caucasian individuals, also identified a new locus at 19q13.33, including NAPSA, a gene which is expressed primarily in alveolar cells responsible for gas exchange in the lung.

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Language(s): eng - English
 Dates: 2022-06-112022-01-142022-07-262022-07-152022-12
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1093/hmg/ddac158
 Degree: -

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Title: Human Molecular Genetics
Source Genre: Journal
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Publ. Info: Oxford, England : IRL Press
Pages: - Volume / Issue: 31 (23) Sequence Number: - Start / End Page: 3945 - 3966 Identifier: ISSN: 0964-6906
CoNE: https://pure.mpg.de/cone/journals/resource/954925581153