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  Mimicry technology: suppressing small RNA activity in plants

Rubio-Somoza, I., & Manavella, P. (2011). Mimicry technology: suppressing small RNA activity in plants. In Methods in Molecular Biology. US: Springer.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000A-D8ED-8 Version Permalink: https://hdl.handle.net/21.11116/0000-000A-D8EE-7
Genre: Book Chapter

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 Creators:
Rubio-Somoza, I1, Author           
Manavella, PA1, Author           
Affiliations:
1Department Molecular Biology, Max Planck Institute for Developmental Biology, Max Planck Society, ou_3375790              

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 Abstract: Small RNA suppression constitutes one of the major difficulties for a full molecular characterization of their specific roles in plants. Taking advantage of the latest insights into the new post-biogenesis layer of regulation in microRNA (miRNA) activity, it is possible to overcome the above-mentioned limitation (Nat Genet 39:1033-1037, 2007). We engineered the IPS1 non-coding RNA to bear a complementary sequence to a given miRNA family, resulting in specific sequestration of RISC complexes. MIMIC technology allows for the constitutive release of all of the potential targets of a miRNA family as well as tissue-specific and inducible suppression of its activity.

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 Dates: 2011
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1007/978-1-61779-083-6_10
PMID: 21431710
 Degree: -

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Title: Methods in Molecular Biology
  Other : Methods Mol. Biol.
Source Genre: Series
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Publ. Info: US : Springer
Pages: - Volume / Issue: 732 Sequence Number: - Start / End Page: - Identifier: ISSN: 1064-3745
CoNE: https://pure.mpg.de/cone/journals/resource/954927725544

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Title: MicroRNAs in Development: Methods and Protocols
Source Genre: Book
 Creator(s):
Dalmay, T, Editor
Affiliations:
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Publ. Info: Totowa, NJ, USA : Humana Press
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: 131 - 137 Identifier: ISBN: 978-1-61779-082-9
DOI: 10.1007/978-1-61779-083-6