English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
 
 
DownloadE-Mail
 Local TagsRelease HistoryDetailsSummary
  Global effects of the small RNA biogenesis machinery on the Arabidopsis thaliana transcriptome

Laubinger, S., Zeller, G., Henz, S., Buechel, S., Sachsenberg, T., Wang, J.-W., et al. (2010). Global effects of the small RNA biogenesis machinery on the Arabidopsis thaliana transcriptome. Proceedings of the National Academy of Sciences of the United States of America, 107(41), 17466-17573. doi:10.1073/pnas.1012891107.

Item is

 

show all hide all

Basic

show hide
Item Permalink: https://hdl.handle.net/21.11116/0000-000A-D939-2 Version Permalink: https://hdl.handle.net/21.11116/0000-000A-D93A-1
Genre: Journal Article

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Laubinger, S, Author           
Zeller, G, Author           
Henz, S, Author           
Buechel, S, Author           
Sachsenberg, T, Author           
Wang, J-W, Author           
Rätsch, G1, Author           
Weigel, D, Author           
Affiliations:
1Rätsch Group, Friedrich Miescher Laboratory, Max Planck Society, ou_3378052              

Content

show
hide
Free keywords: -
 Abstract: In Arabidopsis thaliana, four different dicer-like (DCL) proteins have distinct but partially overlapping functions in the biogenesis of microRNAs (miRNAs) and siRNAs from longer, noncoding precursor RNAs. To analyze the impact of different components of the small RNA biogenesis machinery on the transcriptome, we subjected dcl and other mutants impaired in small RNA biogenesis to whole-genome tiling array analysis. We compared both protein-coding genes and noncoding transcripts, including most pri-miRNAs, in two tissues and several stress conditions. Our analysis revealed a surprising number of common targets in dcl1 and dcl2 dcl3 dcl4 triple mutants. Furthermore, our results suggest that the DCL1 is not only involved in miRNA action but also contributes to silencing of a subset of transposons, apparently through an effect on DNA methylation.

Details

show
hide
Language(s):
 Dates: 2010-10
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1073/pnas.1012891107
PMID: 20870966
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Proceedings of the National Academy of Sciences of the United States of America
  Other : PNAS
  Other : Proceedings of the National Academy of Sciences of the USA
  Abbreviation : Proc. Natl. Acad. Sci. U. S. A.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Washington, D.C. : National Academy of Sciences
Pages: - Volume / Issue: 107 (41) Sequence Number: - Start / End Page: 17466 - 17573 Identifier: ISSN: 0027-8424
CoNE: https://pure.mpg.de/cone/journals/resource/954925427230