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  Evolutionary mechanism as a template for protein engineering

Eisenbeis, S., & Höcker, B. (2010). Evolutionary mechanism as a template for protein engineering. Journal of Peptide Science, 16(10), 538-544. doi:10.1002/psc.1233.

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 Creators:
Eisenbeis, S1, Author           
Höcker, B1, Author           
Affiliations:
1Research Group Protein Design, Max Planck Institute for Developmental Biology, Max Planck Society, ou_3384430              

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 Abstract: The goal of a protein engineer is to adjust a protein to a specified new function. This is exactly what natural evolution has achieved many times. By studying evolutionary mechanisms, we can learn about ways to use the adaptability of proteins and to build new proteins. In fact, many techniques used in engineering are successfully mimicking evolutionary processes. We introduce the fundamental evolutionary mechanisms, take a closer look at duplication and fusion, recombination, and circular permutation and discuss their influence on protein engineering. Some important techniques are presented and illustrated with examples.

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 Dates: 2010-10
 Publication Status: Published in print
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 Rev. Type: -
 Identifiers: DOI: 10.1002/psc.1233
PMID: 20862721
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Title: Journal of Peptide Science
  Other : J. Peptide Sci.
Source Genre: Journal
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Publ. Info: Chichester, West Sussex, UK : John Wiley & Sons
Pages: - Volume / Issue: 16 (10) Sequence Number: - Start / End Page: 538 - 544 Identifier: ISSN: 1075-2617
CoNE: https://pure.mpg.de/cone/journals/resource/954925604784