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  Statistical Tests for Detecting Differential RNA-Transcript Expression from Read Counts

Drewe, P., Stegle, O., Bohnert, R., Borgwardt, K., & Rätsch, G. (2010). Statistical Tests for Detecting Differential RNA-Transcript Expression from Read Counts. Poster presented at 18th Annual International Conference on Intelligent Systems for Molecular Biology (ISMB 2010), Boston, MA, USA.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000A-DA4C-C Version Permalink: https://hdl.handle.net/21.11116/0000-000A-DA4E-A
Genre: Poster

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http://www.iscb.org/uploaded/css/68/18886.pdf (Abstract)
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 Creators:
Drewe, P, Author           
Stegle, O1, Author           
Bohnert, R, Author           
Borgwardt, KM1, Author           
Rätsch, G, Author           
Affiliations:
1Department Molecular Biology, Max Planck Institute for Developmental Biology, Max Planck Society, ou_3375790              

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 Abstract: We present two novel statistical tests for differential abundances of RNA
transcripts: a 'gene structure sensitive' Poisson test when the transcript structure of a gene is
known, and a kernel-based test when it is unknown.
We show that both approaches perform better than testing for differential expression by first quantifying the transcript abundance.

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 Dates: 2010-07
 Publication Status: Published online
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Title: 18th Annual International Conference on Intelligent Systems for Molecular Biology (ISMB 2010)
Place of Event: Boston, MA, USA
Start-/End Date: 2010-07-11 - 2010-07-13

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Title: 18th Annual International Conference on Intelligent Systems for Molecular Biology (ISMB 2010)
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: J51 Start / End Page: - Identifier: -