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  Human larynx motor cortices coordinate respiration for vocal-motor control

Belyk, M., Brown, R., Beal, D. S., Roebroeck, A., McGettigan, C., Guldner, S., et al. (2021). Human larynx motor cortices coordinate respiration for vocal-motor control. NeuroImage, 239: 118326. doi:10.1016/j.neuroimage.2021.118326.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000B-12AE-D Version Permalink: https://hdl.handle.net/21.11116/0000-000C-E18F-5
Genre: Journal Article

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 Creators:
Belyk, Michael1, Author
Brown, Rachel2, 3, Author
Beal, Deryk S.4, 5, Author
Roebroeck, Alard2, Author
McGettigan, Carolyn1, Author
Guldner, Stella6, Author
Kotz, Sonja A.2, 7, Author           
Affiliations:
1Department of Speech, Hearing & Phonetic Sciences, University College London, United Kingdom, ou_persistent22              
2Faculty of Psychology and Neuroscience, Maastricht University, the Netherlands, ou_persistent22              
3Institute of Psychology, RWTH Aachen University, Germany, ou_persistent22              
4Bloorview Research Institute, Toronto, ON, Canada, ou_persistent22              
5Department of Speech-Language Pathology, University of Toronto, ON, Canada, ou_persistent22              
6Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Mannheim, Germany, ou_persistent22              
7Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              

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Free keywords: FMRI; Larynx; Motor cortex; Respiration; Song; Voice; Whistle
 Abstract: Vocal flexibility is a hallmark of the human species, most particularly the capacity to speak and sing. This ability is supported in part by the evolution of a direct neural pathway linking the motor cortex to the brainstem nucleus that controls the larynx the primary sound source for communication. Early brain imaging studies demonstrated that larynx motor cortex at the dorsal end of the orofacial division of motor cortex (dLMC) integrated laryngeal and respiratory control, thereby coordinating two major muscular systems that are necessary for vocalization. Neurosurgical studies have since demonstrated the existence of a second larynx motor area at the ventral extent of the orofacial motor division (vLMC) of motor cortex. The vLMC has been presumed to be less relevant to speech motor control, but its functional role remains unknown. We employed a novel ultra-high field (7T) magnetic resonance imaging paradigm that combined singing and whistling simple melodies to localise the larynx motor cortices and test their involvement in respiratory motor control. Surprisingly, whistling activated both ‘larynx areas’ more strongly than singing despite the reduced involvement of the larynx during whistling. We provide further evidence for the existence of two larynx motor areas in the human brain, and the first evidence that laryngeal-respiratory integration is a shared property of both larynx motor areas. We outline explicit predictions about the descending motor pathways that give these cortical areas access to both the laryngeal and respiratory systems and discuss the implications for the evolution of speech.

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Language(s): eng - English
 Dates: 2021-05-222021-01-132021-06-292021-06-302021-10-01
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/j.neuroimage.2021.118326
Other: epub 2021
PMID: 34216772
 Degree: -

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Project name : -
Grant ID : PDF5029542017
Funding program : -
Funding organization : Natural Sciences and Engineering Research Council of Canada (NSERC)
Project name : -
Grant ID : BB/M009742/1
Funding program : -
Funding organization : Biotechnical and Biological Sciences Research Council of the UK (BBSRC)
Project name : MULTICONNECT
Grant ID : 639938
Funding program : -
Funding organization : European Research Council (ERC)
Project name : -
Grant ID : 14637
Funding program : -
Funding organization : Dutch Science Foundation (NWO)
Project name : -
Grant ID : -
Funding program : -
Funding organization : Kimmel Family Opportunity Fund
Project name : -
Grant ID : -
Funding program : -
Funding organization : Faculty of Psychology and Neuroscience, Maastricht Brain Imaging Center

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Title: NeuroImage
Source Genre: Journal
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Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: 239 Sequence Number: 118326 Start / End Page: - Identifier: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166