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  Sex moderations in the relationship between aortic stiffness, cognition, and cerebrovascular reactivity in healthy older adults

Sabra, D., Intzandt, B., Desjardins-Crepeau, L., Langeard, A., Steele, C., Frouin, F., et al. (2021). Sex moderations in the relationship between aortic stiffness, cognition, and cerebrovascular reactivity in healthy older adults. PLoS One, 16(9): e0257815. doi:10.1371/journal.pone.0257815.

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 Creators:
Sabra, Dalia1, 2, 3, 4, Author
Intzandt, Brittany2, 3, 5, 6, Author
Desjardins-Crepeau, Laurence2, 3, Author
Langeard, Antoine2, 3, 4, Author
Steele, Christopher5, 7, 8, Author           
Frouin, Frédérique9, Author
Hoge, Richard10, 11, Author
Bherer, Louis2, 3, 4, Author
Gauthier, Claudine J.2, 5, 12, Author
Affiliations:
1Department of Biomedical Sciences, University of Montréal, QC, Canada, ou_persistent22              
2Montreal Heart Institute, QC, Canada, ou_persistent22              
3Centre de recherche de l'Institut universitaire de gériatrie de Montréal, QC, Canada, ou_persistent22              
4Faculty of Medicine, University of Montréal, QC, Canada, ou_persistent22              
5PERFORM Center, Concordia University, Montréal, QC, Canada, ou_persistent22              
6INDI Department, Concordia University, Montréal, QC, Canada, ou_persistent22              
7Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
8Department of Psychology, Concordia University, Montréal, QC, Canada, ou_persistent22              
9Institut national de la santé et de la recherche médicale, Institut national de la santé et de la recherche médicale, Orsay, France, ou_persistent22              
10Montreal Neurological Institute and Hospital, McGill University, QC, Canada, ou_persistent22              
11Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, QC, Canada, ou_persistent22              
12Department of Physics, Concordia University, Montréal, QC, Canada, ou_persistent22              

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Free keywords: Aged; Brain; Cerebrovascular Circulation; Cognitive Dysfunction; Female; Healthy Volunteers; Humans; Magnetic Resonance Imaging; Male; Mental Status and Dementia Tests; Middle Aged; Neuropsychological Tests; Pulse Wave Analysis; Sex Characteristics; Spin Labels; Vascular Stiffness
 Abstract: It is well established that sex differences exist in the manifestation of vascular diseases. Arterial stiffness (AS) has been associated with changes in cerebrovascular reactivity (CVR) and cognitive decline in aging. Specifically, older adults with increased AS show a decline on executive function (EF) tasks. Interestingly, the relationship between AS and CVR is more complex, where some studies show decreased CVR with increased AS, and others demonstrate preserved CVR despite higher AS. Here, we investigated the possible role of sex on these hemodynamic relationships. Acquisitions were completed in 48 older adults. Pseudo-continuous arterial spin labeling (pCASL) data were collected during a hypercapnia challenge. Aortic pulse wave velocity (PWV) data was acquired using cine phase contrast velocity series. Cognitive function was assessed with a comprehensive neuropsychological battery, and a composite score for EF was calculated using four cognitive tests from the neuropsychological battery. A moderation model test revealed that sex moderated the relationship between PWV and CVR and PWV and EF, but not between CVR and EF. Together, our results indicate that the relationships between central stiffness, cerebral hemodynamics and cognition are in part mediated by sex. © 2021 Sabra et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Language(s): eng - English
 Dates: 2021-01-122021-09-102021-09-28
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1371/journal.pone.0257815
 Degree: -

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Title: PLoS One
  Abbreviation : PLoS One
Source Genre: Journal
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Publ. Info: San Francisco, CA : Public Library of Science
Pages: - Volume / Issue: 16 (9) Sequence Number: e0257815 Start / End Page: - Identifier: ISSN: 1932-6203
CoNE: https://pure.mpg.de/cone/journals/resource/1000000000277850