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  Diploid hepatocytes drive physiological liver renewal in adult humans

Heinke, P., Rost, F., Rode, J., Trus, P., Simonova, I., Lazar, E., et al. (2022). Diploid hepatocytes drive physiological liver renewal in adult humans. Cell Systems, 13(6), 499-507.e12. doi:10.1016/j.cels.2022.05.001.

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 Creators:
Heinke, Paula1, Author
Rost, Fabian2, Author           
Rode, Julian1, Author
Trus, Palina1, Author
Simonova, Irina1, Author
Lazar, Eniko1, Author
Feddema, Joshua1, Author
Welsch, Thilo1, Author
Alkass, Kanar1, Author
Salehpour, Mehran1, Author
Zimmermann, Andrea1, Author
Seehofer, Daniel1, Author
Possnert, Goran1, Author
Damm, Georg1, Author
Druid, Henrik1, Author
Brusch, Lutz1, Author
Bergmann, Olaf1, Author
Affiliations:
1external, ou_persistent22              
2Max Planck Institute for the Physics of Complex Systems, Max Planck Society, ou_2117288              

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 Abstract: Physiological liver cell replacement is central to maintaining the organ's high metabolic activity, although its characteristics are difficult to study in humans. Using retrospective radiocarbon (C-14) birth dating of cells, we report that human hepatocytes show continuous and lifelong turnover, allowing the liver to remain a young organ (average age <3 years). Hepatocyte renewal is highly dependent on the ploidy level. Diploid hepatocytes show more than 7-fold higher annual birth rates than polyploid hepatocytes. These observations support the view that physiological liver cell renewal in humans is mainly dependent on diploid hepatocytes, whereas polyploid cells are compromised in their ability to divide. Moreover, cellular transitions between diploid and polyploid hepatocytes are limited under homeostatic conditions. With these findings, we present an integrated model of homeostatic liver cell generation in humans that provides fundamental insights into liver cell turnover dynamics.

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Language(s): eng - English
 Dates: 2022-05-312022-06-15
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
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Title: Cell Systems
Source Genre: Journal
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Publ. Info: Maryland Heights, MO : Elsevier
Pages: - Volume / Issue: 13 (6) Sequence Number: - Start / End Page: 499 - 507.e12 Identifier: ISSN: 2405-4720
CoNE: https://pure.mpg.de/cone/journals/resource/2405-4720