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  The plant circadian clock regulates autophagy rhythm through transcription factor LUX ARRHYTHMO

Yang, M.-K., Zhu, X.-J., Chen, C.-M., Guo, X., Xu, S.-X., Xu, Y.-R., et al. (2022). The plant circadian clock regulates autophagy rhythm through transcription factor LUX ARRHYTHMO. Journal of Integrative Plant Biology, 64(11), 2135-2149. doi:10.1111/jipb.13343.

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Genre: Journal Article
Alternative Title : Journal of Integrative Plant Biology

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 Creators:
Yang, Ming-Kang1, Author
Zhu, Xiao-Jie1, Author
Chen, Chu-Min1, Author
Guo, Xu1, Author
Xu, Shu-Xuan1, Author
Xu, Ya-Rou1, Author
Du, Shen-Xiu1, Author
Xiao, Shi1, Author
Mueller-Roeber, B.2, Author           
Huang, Wei1, Author
Chen, Liang1, Author
Affiliations:
1external, ou_persistent22              
2Plant Signalling, Cooperative Research Groups, Max Planck Institute of Molecular Plant Physiology, Max Planck Society, ou_1753311              

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Free keywords: autophagy, carbon starvation, circadian clock, LUX, rhythm
 Abstract: ABSTRACT Autophagy is an evolutionarily conserved degradation pathway in eukaryotes; it plays a critical role in nutritional stress tolerance. The circadian clock is an endogenous timekeeping system that generates biological rhythms to adapt to daily changes in the environment. Accumulating evidence indicates that the circadian clock and autophagy are intimately interwoven in animals. However, the role of the circadian clock in regulating autophagy has been poorly elucidated in plants. Here, we show that autophagy exhibits a robust circadian rhythm in both light/dark cycle (LD) and in constant light (LL) in Arabidopsis. However, autophagy rhythm showed a different pattern with a phase-advance shift and a lower amplitude in LL compared to LD. Moreover, mutation of the transcription factor LUX ARRHYTHMO (LUX) removed autophagy rhythm in LL and led to an enhanced amplitude in LD. LUX represses expression of the core autophagy genes ATG2, ATG8a, and ATG11 by directly binding to their promoters. Phenotypic analysis revealed that LUX is responsible for improved resistance of plants to carbon starvation, which is dependent on moderate autophagy activity. Comprehensive transcriptomic analysis revealed that the autophagy rhythm is ubiquitous in plants. Taken together, our findings demonstrate that the LUX-mediated circadian clock regulates plant autophagy rhythms. This article is protected by copyright. All rights reserved.

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Language(s): eng - English
 Dates: 2022-08-132022-11
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1111/jipb.13343
 Degree: -

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Title: Journal of Integrative Plant Biology
Source Genre: Journal
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Publ. Info: Beijing : Blackwell Publ. Asia Pty
Pages: - Volume / Issue: 64 (11) Sequence Number: - Start / End Page: 2135 - 2149 Identifier: ISSN: 1672-9072
CoNE: https://pure.mpg.de/cone/journals/resource/1672-9072