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  Inter-individual body mass variations relate to fractionated functional brain hierarchies

Park, B.-y., Park, H., Morys, F., Kim, M., Byeon, K., Lee, H., Kim, S.-H., Valk, S. L., Dagher, A., & Bernhardt, B. C. (2021). Inter-individual body mass variations relate to fractionated functional brain hierarchies. Communications Biology, 4(1):. doi:10.1038/s42003-021-02268-x.

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アイテムのパーマリンク: https://hdl.handle.net/21.11116/0000-000B-135B-A 版のパーマリンク: https://hdl.handle.net/21.11116/0000-000D-6F3E-3
資料種別: 学術論文

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Park_Park_2021.pdf (出版社版), 2MB
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ファイルのパーマリンク:
https://hdl.handle.net/21.11116/0000-000B-135D-8
ファイル名:
Park_Park_2021.pdf
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公開
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CCライセンス:
https://creativecommons.org/licenses/by/4.0/

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作成者

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 作成者:
Park, Bo-yong1, 2, 著者
Park, Hyunjin3, 4, 著者
Morys, Filip1, 著者
Kim, Mansu5, 著者
Byeon, Kyoungseob4, 6, 著者
Lee, Hyebin4, 6, 著者
Kim, Se-Hong7, 著者
Valk, Sofie L.8, 9, 著者           
Dagher, Alain1, 著者
Bernhardt, Boris C.1, 著者
所属:
1Montreal Neurological Institute and Hospital, McGill University, Montréal, QC, Canada, ou_persistent22              
2Department of Data Science, Inha University, Incheon, Republic of Korea, ou_persistent22              
3School of Electronic and Electrical Engineering, Sungkyunkwan University, Seoul, Republic of Korea, ou_persistent22              
4Center for Neuroscience Imaging Research, Institute for Basic Science, Daejeon, Republic of Korea, ou_persistent22              
5Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA, USA, ou_persistent22              
6Department of Electrical and Computer Engineering, Sungkyunkwan University, Seoul, Republic of Korea, ou_persistent22              
7Department of Family Medicine, Catholic University of Korea School of Medicine, Seoul, Republic of Korea, ou_persistent22              
8Otto Hahn Group Cognitive Neurogenetics, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_3222264              
9Institute of Neuroscience and Medicine, Research Center Jülich, Germany, ou_persistent22              

内容説明

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キーワード: Surface-based analysis; Sleep quality index; Resting-state; Network centrality; Neural mechanisms; Eating behaviors; Reward systems; Food reward; Obesity; Connectivity
 要旨: Variations in body mass index (BMI) have been suggested to relate to atypical brain organization, yet connectome-level substrates of BMI and their neurobiological underpinnings remain unclear. Studying 325 healthy young adults, we examined associations between functional connectivity and inter-individual BMI variations. We utilized non-linear connectome manifold learning techniques to represent macroscale functional organization along continuous hierarchical axes that dissociate low level and higher order brain systems. We observed an increased differentiation between unimodal and heteromodal association networks in individuals with higher BMI, indicative of a disrupted modular architecture and hierarchy of the brain. Transcriptomic decoding and gene enrichment analyses identified genes previously implicated in genome-wide associations to BMI and specific cortical, striatal, and cerebellar cell types. These findings illustrate functional connectome substrates of BMI variations in healthy young adults and point to potential molecular associations. Bo-yong Park et al. use non-linear connectome manifold learning to examine the association between brain connectivity and inter-individual body mass index (BMI) in 325 young adults. They supplement these analyses with existing transcriptomic data, altogether suggesting several neural and molecular associations that may underlie BMI variations in healthy young adults.

資料詳細

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言語: eng - English
 日付: 2020-11-102021-05-062021-06-14
 出版の状態: オンラインで出版済み
 ページ: -
 出版情報: -
 目次: -
 査読: -
 識別子（DOI, ISBNなど）: DOI: 10.1038/s42003-021-02268-x
PMID: 34127795
PMC: PMC8203627
 学位: -

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訴訟

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Project information

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Project name : -
Grant ID : 64617-01
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Funding organization : Inha University
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Grant ID : NRF-2020R1A6A3A03037088
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Funding organization : National Research Foundation of Korea
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Grant ID : Discovery-1304413
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Funding organization : National Science and Engineering Research Council of Canada (NSERC)
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Grant ID : FDN-154298; PJT-174995
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Funding organization : Canadian Institutes of Health Research (CIHR)
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Grant ID : NI17-039
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Funding organization : SickKids Foundation
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Funding organization : Montreal Neurological Institute and Hospital (MNI)
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Funding organization : Fonds de la Recherche du Québec – Santé (FRQ-S)
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Funding organization : Azrieli Center for Autism Research (ACAR-TACC)
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Funding organization : BrainCanada
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Funding organization : Helmholtz Foundation

出版物 1

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出版物名: Communications Biology
種別: 学術雑誌
 著者・編者:
所属:
出版社, 出版地: London : Springer Nature
ページ: - 巻号: 4 (1) 通巻号: 735 開始・終了ページ: - 識別子（ISBN, ISSN, DOIなど）: ISSN: 2399-3642
CoNE: https://pure.mpg.de/cone/journals/resource/2399-3642