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  Tethering of cellulose synthase to microtubules dampens mechano-induced cytoskeletal organization in Arabidopsis pavement cells

Schneider, R., Ehrhardt, D. W., Meyerowitz, E. M., & Sampathkumar, A. (2022). Tethering of cellulose synthase to microtubules dampens mechano-induced cytoskeletal organization in Arabidopsis pavement cells. Nature Plants, 8, 1064-1073. doi:10.1038/s41477-022-01218-7.

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 Creators:
Schneider, R.1, Author           
Ehrhardt, David W.2, Author
Meyerowitz, Elliot M.2, Author
Sampathkumar, A.1, Author           
Affiliations:
1Plant Cell Biology and Microscopy, Infrastructure Groups and Service Units, Max Planck Institute of Molecular Plant Physiology, Max Planck Society, ou_2253647              
2external, ou_persistent22              

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 Abstract: Mechanical forces control development in plants and animals, acting as cues in pattern formation and as the driving force of morphogenesis. In mammalian cells, molecular assemblies residing at the interface of the cell membrane and the extracellular matrix play an important role in perceiving and transmitting external mechanical signals to trigger physiological responses. Similar processes occur in plants, but there is little understanding of the molecular mechanisms and their genetic basis. Here, we show that the number and movement directions of cellulose synthase complexes (CSCs) at the plasma membrane vary during initial stages of development in the cotyledon epidermis of Arabidopsis, closely mirroring the microtubule organization. Uncoupling microtubules and CSCs resulted in enhanced microtubule co-alignment as caused by mechanical stimuli driven either by cell shape or by tissue-scale physical perturbations. Furthermore, micromechanical perturbation resulted in depletion of CSCs from the plasma membrane, suggesting a possible link between cellulose synthase removal from the plasma membrane and microtubule response to mechanical stimuli. Taken together, our results suggest that the interaction of cellulose synthase with cortical microtubules forms a physical continuum between the cell wall, plasma membrane and the cytoskeleton that modulates the mechano-response of the cytoskeleton.

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Language(s): eng - English
 Dates: 2022-08-182022-08-18
 Publication Status: Published in print
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 Identifiers: DOI: 10.1038/s41477-022-01218-7
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Title: Nature Plants
Source Genre: Journal
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Publ. Info: Nature Publishing Group
Pages: - Volume / Issue: 8 Sequence Number: - Start / End Page: 1064 - 1073 Identifier: ISSN: 2055-0278
CoNE: https://pure.mpg.de/cone/journals/resource/2055-0278