Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT
Zur Ablage hinzufügen
 Lokale TagsFreigabegeschichteDetailsÜbersicht
  Heritability and cross-species comparisons of human cortical functional organization asymmetry

Wan, B., Bayrak, S., Xu, T., Schaare, H. L., Bethlehem, R. A. I., Bernhardt, B. C., et al. (2022). Heritability and cross-species comparisons of human cortical functional organization asymmetry. eLife, 11: e77215. doi:10.7554/eLife.77215.

Item is

 

einblenden: alle ausblenden: alle

Basisdaten

einblenden: ausblenden:
Datensatz-Permalink: https://hdl.handle.net/21.11116/0000-000A-E18A-C Versions-Permalink: https://hdl.handle.net/21.11116/0000-000E-01A1-A
Genre: Zeitschriftenartikel

Dateien

einblenden: Dateien
ausblenden: Dateien
:
Wan_2022.pdf (Verlagsversion), 10MB
Öffnen   Speichern
Datei-Permalink:
https://hdl.handle.net/21.11116/0000-000A-E18C-A
Name:
Wan_2022.pdf
Beschreibung:
-
OA-Status:
Gold
Sichtbarkeit:
Öffentlich
MIME-Typ / Prüfsumme:
application/pdf / [MD5]
Technische Metadaten:
Öffnen
Copyright Datum:
-
Copyright Info:
-
Lizenz:
https://creativecommons.org/licenses/by/4.0/

Externe Referenzen

einblenden:

Urheber

einblenden:
ausblenden:
 Urheber:
Wan, Bin1, 2, 3, 4, Autor           
Bayrak, Seyma1, 3, 4, Autor           
Xu, Ting5, Autor
Schaare, Herma Lina1, 4, Autor           
Bethlehem, Richard A. I.6, Autor
Bernhardt, Boris C.7, Autor
Valk, Sofie L.1, 4, 8, Autor           
Affiliations:
1Otto Hahn Group Cognitive Neurogenetics, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_3222264              
2International Max Planck Research School on Neuroscience of Communication: Function, Structure, and Plasticity, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_2616696              
3Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
4Institute of Neuroscience and Medicine, Research Center Jülich, Germany, ou_persistent22              
5Center for the Developing Brain, Child Mind Institute, New York, NY, USA, ou_persistent22              
6Department of Psychiatry, University of Cambridge, United Kingdom, ou_persistent22              
7McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montréal, QC, Canada, ou_persistent22              
8Institute of Systems Neuroscience, University Hospital Düsseldorf, Germany, ou_persistent22              

Inhalt

einblenden:
ausblenden:
Schlagwörter: Asymmetry; Cerebral cortex; Evolution; Functional gradients; Heritability; Human; Large-scale organization; Neuroscience; Rhesus macaque
 Zusammenfassung: The human cerebral cortex is symmetrically organized along large-scale axes but also presents inter-hemispheric differences in structure and function. The quantified contralateral homologous difference, that is asymmetry, is a key feature of the human brain left-right axis supporting functional processes, such as language. Here, we assessed whether the asymmetry of cortical functional organization is heritable and phylogenetically conserved between humans and macaques. Our findings indicate asymmetric organization along an axis describing a functional trajectory from perceptual/action to abstract cognition. Whereas language network showed leftward asymmetric organization, frontoparietal network showed rightward asymmetric organization in humans. These asymmetries were heritable in humans and showed a similar spatial distribution with macaques, in the case of intra-hemispheric asymmetry of functional hierarchy. This suggests (phylo)genetic conservation. However, both language and frontoparietal networks showed a qualitatively larger asymmetry in humans relative to macaques. Overall, our findings suggest a genetic basis for asymmetry in intrinsic functional organization, linked to higher order cognitive functions uniquely developed in humans.

Details

einblenden:
ausblenden:
Sprache(n): eng - English
 Datum: 2022-01-202022-07-282022-07-29
 Publikationsstatus: Online veröffentlicht
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: DOI: 10.7554/eLife.77215
PMID: 35904242
PMC: PMC9381036
 Art des Abschluß: -

Veranstaltung

einblenden:

Entscheidung

einblenden:

Projektinformation

einblenden: ausblenden:
Projektname : -
Grant ID : -
Förderprogramm : -
Förderorganisation : Max-Planck-Gesellschaft
Projektname : -
Grant ID : NI17-039
Förderprogramm : -
Förderorganisation : Sick Kids Foundation
Projektname : -
Grant ID : Discovery-1304413
Förderprogramm : -
Förderorganisation : Natural Sciences and Engineering Research Council of Canada (NSERC)
Projektname : -
Grant ID : FDN154298
Förderprogramm : -
Förderorganisation : Canadian Institutes of Health Research (CIHR)
Projektname : -
Grant ID : -
Förderprogramm : -
Förderorganisation : Azrieli Center for Autism Research
Projektname : -
Grant ID : -
Förderprogramm : -
Förderorganisation : Canada First Research Excellence Fund
Projektname : -
Grant ID : -
Förderprogramm : -
Förderorganisation : International Max Planck Research School on Neuroscience of Communication: Function, Structure, and Plasticity

Quelle 1

einblenden:
ausblenden:
Titel: eLife
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Cambridge : eLife Sciences Publications
Seiten: - Band / Heft: 11 Artikelnummer: e77215 Start- / Endseite: - Identifikator: ISSN: 2050-084X
CoNE: https://pure.mpg.de/cone/journals/resource/2050-084X