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  Heritability and cross-species comparisons of human cortical functional organization asymmetry

Wan, B., Bayrak, S., Xu, T., Schaare, H. L., Bethlehem, R. A. I., Bernhardt, B. C., et al. (2022). Heritability and cross-species comparisons of human cortical functional organization asymmetry. eLife, 11: e77215. doi:10.7554/eLife.77215.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000A-E18A-C Version Permalink: https://hdl.handle.net/21.11116/0000-000E-01A1-A
Genre: Journal Article

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 Creators:
Wan, Bin1, 2, 3, 4, Author           
Bayrak, Seyma1, 3, 4, Author           
Xu, Ting5, Author
Schaare, Herma Lina1, 4, Author           
Bethlehem, Richard A. I.6, Author
Bernhardt, Boris C.7, Author
Valk, Sofie L.1, 4, 8, Author           
Affiliations:
1Otto Hahn Group Cognitive Neurogenetics, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_3222264              
2International Max Planck Research School on Neuroscience of Communication: Function, Structure, and Plasticity, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_2616696              
3Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
4Institute of Neuroscience and Medicine, Research Center Jülich, Germany, ou_persistent22              
5Center for the Developing Brain, Child Mind Institute, New York, NY, USA, ou_persistent22              
6Department of Psychiatry, University of Cambridge, United Kingdom, ou_persistent22              
7McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montréal, QC, Canada, ou_persistent22              
8Institute of Systems Neuroscience, University Hospital Düsseldorf, Germany, ou_persistent22              

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Free keywords: Asymmetry; Cerebral cortex; Evolution; Functional gradients; Heritability; Human; Large-scale organization; Neuroscience; Rhesus macaque
 Abstract: The human cerebral cortex is symmetrically organized along large-scale axes but also presents inter-hemispheric differences in structure and function. The quantified contralateral homologous difference, that is asymmetry, is a key feature of the human brain left-right axis supporting functional processes, such as language. Here, we assessed whether the asymmetry of cortical functional organization is heritable and phylogenetically conserved between humans and macaques. Our findings indicate asymmetric organization along an axis describing a functional trajectory from perceptual/action to abstract cognition. Whereas language network showed leftward asymmetric organization, frontoparietal network showed rightward asymmetric organization in humans. These asymmetries were heritable in humans and showed a similar spatial distribution with macaques, in the case of intra-hemispheric asymmetry of functional hierarchy. This suggests (phylo)genetic conservation. However, both language and frontoparietal networks showed a qualitatively larger asymmetry in humans relative to macaques. Overall, our findings suggest a genetic basis for asymmetry in intrinsic functional organization, linked to higher order cognitive functions uniquely developed in humans.

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Language(s): eng - English
 Dates: 2022-01-202022-07-282022-07-29
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.7554/eLife.77215
PMID: 35904242
PMC: PMC9381036
 Degree: -

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Funding organization : Max-Planck-Gesellschaft
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Grant ID : NI17-039
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Funding organization : Sick Kids Foundation
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Grant ID : Discovery-1304413
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Funding organization : Natural Sciences and Engineering Research Council of Canada (NSERC)
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Grant ID : FDN154298
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Funding organization : Canadian Institutes of Health Research (CIHR)
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Funding organization : Azrieli Center for Autism Research
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Funding organization : Canada First Research Excellence Fund
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Funding program : -
Funding organization : International Max Planck Research School on Neuroscience of Communication: Function, Structure, and Plasticity

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Title: eLife
Source Genre: Journal
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Publ. Info: Cambridge : eLife Sciences Publications
Pages: - Volume / Issue: 11 Sequence Number: e77215 Start / End Page: - Identifier: ISSN: 2050-084X
CoNE: https://pure.mpg.de/cone/journals/resource/2050-084X