English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Semi-synthetic glycoconjugate vaccine lead against Acinetobacter baumannii 17978

Sianturi, J., Priegue, P., Hu, J., Yin, J., & Seeberger, P. H. (2022). Semi-synthetic glycoconjugate vaccine lead against Acinetobacter baumannii 17978. Angewandte Chemie International Edition, 61(41): e202209556. doi:10.1002/anie.202209556.

Item is

Files

show Files
hide Files
:
Article.pdf (Publisher version), 8MB
Name:
Article.pdf
Description:
-
OA-Status:
Hybrid
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-

Locators

show

Creators

show
hide
 Creators:
Sianturi, Julinton1, Author           
Priegue, Patricia1, Author           
Hu, Jing, Author
Yin, Jian, Author
Seeberger, Peter H.1, Author                 
Affiliations:
1Peter H. Seeberger - Vaccine Development, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863308              

Content

show
hide
Free keywords: Acinetobacter baumannii; carbohydrate; glycans; total synthesis; immunology
 Abstract: Acinetobacter baumannii is a opportunistic bacterial pathogen responsible for serious nosocomial infections that is becoming increasingly resistant against antibiotics. Capsular polysaccharides (CPS) that cover A. baumannii are a major virulence factor that play an important role in pathogenesis, are used to assign serotypes and provide the basis for vaccine development. Synthetic oligosaccharides resembling the CPS of A. baumannii 17978 were printed onto microarray slides and used to screen sera from patients infected with A. baumannii as well as a monoclonal mouse antibody (mAb C8). A synthetic oligosaccharide emerged from glycan array screening as lead for the development of a vaccine against A. baumannii 17978. Tetrasaccharide 20 is a key epitope for recognition by an antibody and is a vaccine lead.

Details

show
hide
Language(s): eng - English
 Dates: 2022-08-112022
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Angewandte Chemie International Edition
  Abbreviation : Angew. Chem., Int. Ed.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Weinheim : Wiley-VCH
Pages: - Volume / Issue: 61 (41) Sequence Number: e202209556 Start / End Page: - Identifier: ISSN: 1433-7851

Source 2

show
hide
Title: Angewandte Chemie
  Abbreviation : Angew. Chem.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Weinheim : Wiley-VCH
Pages: - Volume / Issue: 134 (41) Sequence Number: e202209556 Start / End Page: - Identifier: ISSN: 0044-8249