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  Selection against admixture and gene regulatory divergence in a long-term primate field study

Vilgalys, T. P., Fogel, A. S., Anderson, J. A., Mututua, R. S., Warutere, J. K., Siodi, I. L., et al. (2022). Selection against admixture and gene regulatory divergence in a long-term primate field study. Science, 377(6606), 635-641. doi:10.1126/science.abm4917.

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Genre: Zeitschriftenartikel
Alternativer Titel : Science

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Vilgalys, Tauras P., Autor
Fogel, Arielle S., Autor
Anderson, Jordan A., Autor
Mututua, Raphael S., Autor
Warutere, J. Kinyua, Autor
Siodi, I. Long’ida, Autor
Kim, Sang Yoon, Autor
Voyles, Tawni N., Autor
Robinson, Jacqueline A., Autor
Wall, Jeffrey D., Autor
Archie, Elizabeth A., Autor
Alberts, Susan C., Autor
Tung, Jenny1, Autor                 
Affiliations:
1Department of Primate Behavior and Evolution, Max Planck Institute for Evolutionary Anthropology, Max Planck Society, ou_3367832              

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 Zusammenfassung: Genetic admixture is central to primate evolution. We combined 50 years of field observations of immigration and group demography with genomic data from ~9 generations of hybrid baboons to investigate the consequences of admixture in the wild. Despite no obvious fitness costs to hybrids, we found signatures of selection against admixture similar to those described for archaic hominins. These patterns were concentrated near genes where ancestry is strongly associated with gene expression. Our analyses also show that introgression is partially predictable across the genome. This study demonstrates the value of integrating genomic and field data for revealing how ?genomic signatures of selection? (e.g., reduced introgression in low-recombination regions) manifest in nature; moreover, it underscores the importance of other primates as living models for human evolution. Today, humans are the only extant members of our genus, Homo. This was not the case in the past, as we now know that our ancestors shared the planet with other Homo species. It has been suggested that selection against hybrid individuals would have acted against breeding across these species, but such a hypothesis is difficult to test today. To study this question, Vilgalys et al. took advantage of a decades-long dataset on two species of baboon from the Amboseli basin of Kenya. They found evidence of selection against hybrid, or admixed, ancestry similar to what has been predicted for ancestral hominids. Although evidence for selection against hybrids was clear, they also found that individual hybrids can thrive. ?SNV Coupled genomic and field data indicate selection against baboon hybrids despite no overt fitness costs in the wild.

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Sprache(n): eng - English
 Datum: 2022-08
 Publikationsstatus: Erschienen
 Seiten: 7
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1126/science.abm4917
 Art des Abschluß: -

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Titel: Science
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: American Association for the Advancement of Science (AAAS)
Seiten: - Band / Heft: 377 (6606) Artikelnummer: - Start- / Endseite: 635 - 641 Identifikator: ISSN: 1095-9203
ISSN: 0036-8075