The Human Intestinal Microbiota and Microbiome

Koren, O; Ley, RE

doi:10.1002/9781118512074.ch32

Local TagsRelease HistoryDetailsSummary

The Human Intestinal Microbiota and Microbiome

Koren, O., & Ley, R. (2016). The Human Intestinal Microbiota and Microbiome. In D. Podolski, M. Camilleri, J. Fitz, A. Kalloo, F. Shanahan, & T. Wang (Eds.), Yamada' s Textbook of Gastroenterology (6th, pp. 617-625). Chichester, UK: John Wiley & Sons Inc.

Item is Released

show all hide all

Basic

show hide

Item Permalink: https://hdl.handle.net/21.11116/0000-000A-E7E2-2 Version Permalink: https://hdl.handle.net/21.11116/0000-000A-ECB7-E

Genre: Book Chapter

Files

show Files

Locators

show

Creators

show

hide

Creators:
Koren, O, Author
Ley, RE¹, Author

Affiliations:
1External Organizations, ou_persistent22

Content

show

hide

Free keywords: -

Abstract: The microbiota has a major impact on health through interactions with host cells (including components of the innate and adaptive immune systems), through extraction of nutrients and energy from the diet, and through complex biotransformations (e.g., detoxification) of a variety of ingested compounds, including potential carcinogens. To date, two major projects have characterized the healthy human gut microbiota on a large scale: the Metagenomics for the Human Intestinal Tract (MetaHIT) consortium (primarily European and Chinese partners) and the Human Microbiome Project (HMP) consortium. Many diseases associated with an altered gut microbiota are also related to host genetic factors, which have been shown independently to alter the microbiota. One of the best examples of this is Crohn's disease. Variants in genes associated with the adaptive immune system have also been implicated in human disease, and these may play a role in shaping the microbiome.

Details

show

hide

Language(s):

Dates: Date issued: 2016

Publication Status: Issued

Pages: -

Publishing info: -

Table of Contents: -

Rev. Type: -

Identifiers: DOI: 10.1002/9781118512074.ch32

Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show

hide

Title: Yamada' s Textbook of Gastroenterology

Source Genre: Book

Creator(s):
Podolski, DK, Editor
Camilleri, M, Editor
Fitz, JG, Editor
Kalloo, AN, Editor
Shanahan, F, Editor
Wang, TC, Editor

Affiliations:
-

Publ. Info: Chichester, UK : John Wiley & Sons Inc., 6th

Pages: - Volume / Issue: - Sequence Number: 32 Start / End Page: 617 - 625 Identifier: ISBN: 978-1-118-51206-7