ausblenden:
Schlagwörter:
computational neuroscience
branching
dendrite
morphology
minimum spanning tree
adult-born neurons
synaptic connectivity
optimization
morphologies
principles
number
arbors
dscam
tree
Zusammenfassung:
The wide diversity of dendritic trees is one of the most striking features of neural circuits. Here we develop a general quantitative theory relating the total length of dendritic wiring to the number of branch points and synapses. We show that optimal wiring predicts a 2/3 power law between these measures. We demonstrate that the theory is consistent with data from a wide variety of neurons across many different species and helps define the computational compartments in dendritic trees. Our results imply fundamentally distinct design principles for dendritic arbors compared with vascular, bronchial, and botanical trees.
