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  Increased serum NSE and S100B indicate neuronal and glial alterations in subjects under 71 years with mild neurocognitive disorder/mild cognitive impairment

Polyakova, M., Mueller, K., Arélin, K., Lampe, L., Rodriguez, F. S., Luck, T., et al. (2022). Increased serum NSE and S100B indicate neuronal and glial alterations in subjects under 71 years with mild neurocognitive disorder/mild cognitive impairment. Frontiers in Cellular Neuroscience, 16: 788150. doi:10.3389/fncel.2022.788150.

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 Creators:
Polyakova, Maryna1, 2, 3, 4, Author           
Mueller, Karsten5, 6, Author           
Arélin, Katrin1, 3, Author           
Lampe, Leonie1, 3, Author           
Rodriguez, Francisca S.3, 7, Author
Luck, Tobias3, 8, Author
Kratzsch, Jürgen3, 9, Author
Hoffmann, Karl-Titus10, Author
Riedel-Heller, Steffi3, 11, Author
Villringer, Arno1, 3, 10, Author           
Schoenknecht, Peter3, 4, 12, Author
Schroeter, Matthias L.1, 2, 3, Author           
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
3Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, Germany, ou_persistent22              
4Department of Psychiatry and Psychotherapy, University Hospital Leipzig, Germany, ou_persistent22              
5Method and Development Group Neural Data Science and Statistical Computing, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_3282987              
6Methods and Development Group Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634558              
7German Center for Neurodegenerative Diseases (DZNE), Greifswald, Germany, ou_persistent22              
8Faculty of Applied Social Sciences, University of Applied Sciences, Erfurt, Germany, ou_persistent22              
9Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics (ILM), University of Leipzig, Germany, ou_persistent22              
10Institute for Neuroradiology, University Hospital Leipzig, Germany, ou_persistent22              
11Institute of Social Medicine, Occupational Health and Public Health (ISAP), University Hospital Leipzig, Germany, ou_persistent22              
12Department of Psychiatry and Psychotherapy, TU Dresden, Germany, ou_persistent22              

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Free keywords: BDNF; Brain-Derived Neurotrophic Factor; NSE; S100B; Mild cognitive impairment; Neuron-specific enolase; White matter hyperintensities
 Abstract: Background: Mild cognitive impairment (MCI) is considered a pre-stage of different dementia syndromes. Despite diagnostic criteria refined by DSM-5 and a new term for MCI - "mild neurocognitive disorder" (mild NCD) - this diagnosis is still based on clinical criteria.

Methods: To link mild NCD to the underlying pathophysiology we assessed the degree of white matter hyperintensities (WMH) in the brain and peripheral biomarkers for neuronal integrity (neuron-specific enolase, NSE), plasticity (brain-derived neurotrophic factor, BDNF), and glial function (S100B) in 158 community-dwelling subjects with mild NCD and 82 healthy controls. All participants (63-79 years old) were selected from the Leipzig-population-based study of adults (LIFE).

Results: Serum S100B levels were increased in mild NCD in comparison to controls (p = 0.007). Serum NSE levels were also increased but remained non-significant after Bonferroni-Holm correction (p = 0.04). Furthermore, age by group interaction was significant for S100B. In an age-stratified sub-analysis, NSE and S100B were higher in younger subjects with mild NCD below 71 years of age. Some effects were inconsistent after controlling for potentially confounding factors. The discriminatory power of the two biomarkers NSE and S100B was insufficient to establish a pathologic threshold for mild NCD. In subjects with mild NCD, WMH load correlated with serum NSE levels (r = 0.20, p = 0.01), independently of age.

Conclusion: Our findings might indicate the presence of neuronal (NSE) and glial (S100B) injury in mild NCD. Future studies need to investigate whether younger subjects with mild NCD with increased biomarker levels are at risk of developing major NCD.

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Language(s): eng - English
 Dates: 2021-10-012022-05-272022-07-14
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.3389/fncel.2022.788150
Other: eCollection 2022
PMID: 35910248
PMC: PMC9329528
 Degree: -

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Title: Frontiers in Cellular Neuroscience
  Other : Front. Cell. Neurosci.
  Abbreviation : FNCEL
Source Genre: Journal
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Publ. Info: Lausanne : Frontiers Media
Pages: - Volume / Issue: 16 Sequence Number: 788150 Start / End Page: - Identifier: ISSN: 1664-8714
ISSN: 1662-5102
CoNE: https://pure.mpg.de/cone/journals/resource/1662-5102