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  CYP2C19 expression modulates affective functioning and hippocampal subiculum volume: A large single-center community-dwelling cohort study

Grosu, C., Trofimova, O., Gholam-Rezaee, M., Strippoli, M.-P.-F., Kherif, F., Lutti, A., et al. (2022). CYP2C19 expression modulates affective functioning and hippocampal subiculum volume: A large single-center community-dwelling cohort study. Translational Psychiatry, 12(1): 316. doi:10.1038/s41398-022-02091-w.

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 Creators:
Grosu, Claire1, Author
Trofimova, Olga2, Author
Gholam-Rezaee, Mehdi3, Author
Strippoli, Marie-Pierre F.3, Author
Kherif, Ferath2, Author
Lutti, Antoine2, Author
Preisig, Martin3, Author
Draganski, Bogdan2, 4, Author           
Eap, Chin B.1, 5, 6, 7, Author
Affiliations:
1Department of Psychiatry, Centre hospitalier universitaire vaudois, Lausanne, Switzerland, ou_persistent22              
2Département des Neurosciences Cliniques, Laboratoire de Recherche en Neuroimagerie (LREN), Centre hospitalier universitaire vaudois, Lausanne, Switzerland, ou_persistent22              
3Center for Psychiatric Epidemiology and Psychopathology, Centre hospitalier universitaire vaudois, Lausanne, Switzerland, ou_persistent22              
4Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
5School of Pharmaceutical Sciences, University of Geneva, Switzerland, ou_persistent22              
6Center for Research and Innovation in Clinical Pharmaceutical Sciences, Centre hospitalier universitaire vaudois, Lausanne, Switzerland, ou_persistent22              
7Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Switzerland, ou_persistent22              

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Free keywords: Neuroscience; Psychology
 Abstract: Given controversial findings of reduced depressive symptom severity and increased hippocampus volume in CYP2C19 poor metabolizers, we sought to provide empirical evidence from a large-scale single-center longitudinal cohort in the community-dwelling adult population-Colaus|PsyCoLaus in Lausanne, Switzerland (n = 4152). We looked for CYP2C19 genotype-related behavioral and brain anatomy patterns using a comprehensive set of psychometry, water diffusion- and relaxometry-based magnetic resonance imaging (MRI) data (BrainLaus, n = 1187). Our statistical models tested for differential associations between poor metabolizer and other metabolizer status with imaging-derived indices of brain volume and tissue properties that explain individuals' current and lifetime mood characteristics. The observed association between CYP2C19 genotype and lifetime affective status showing higher functioning scores in poor metabolizers, was mainly driven by female participants (ß = 3.9, p = 0.010). There was no difference in total hippocampus volume between poor metabolizer and other metabolizer, though there was higher subiculum volume in the right hippocampus of poor metabolizers (ß = 0.03, pFDRcorrected = 0.036). Our study supports the notion of association between mood phenotype and CYP2C19 genotype, however, finds no evidence for concomitant hippocampus volume differences, with the exception of the right subiculum.

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Language(s): eng - English
 Dates: 2022-07-192021-11-082022-07-212022-08-05
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1038/s41398-022-02091-w
PMID: 35931695
PMC: PMC9356029
 Degree: -

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Grant ID : 320030_184784, 320030_200602, 3200B0–105993, 3200B0-118308, 33CSCO-122661, 33CS30-139468, 33CS30-148401, 33CS30_177535, 32003B_159780, CRSK-3_190185 and 324730_192755
Funding program : -
Funding organization : Swiss National Science Foundation

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Title: Translational Psychiatry
  Abbreviation : Transl Psychiatry
Source Genre: Journal
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Publ. Info: Nature Pub. Group
Pages: - Volume / Issue: 12 (1) Sequence Number: 316 Start / End Page: - Identifier: ISSN: 2158-3188
CoNE: https://pure.mpg.de/cone/journals/resource/2158-3188