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  Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning

Lahti, J., Tuominen, S., Yang, Q., Pergola, G., Ahmad, S., Amin, N., et al. (2022). Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning. Molecular Psychiatry. doi:10.1038/s41380-022-01710-8.

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 Creators:
Lahti, Jari1, Author
Tuominen, Samuli1, Author
Yang, Qiong1, Author
Pergola, Giulio1, Author
Ahmad, Shahzad1, Author
Amin, Najaf1, Author
Armstrong, Nicola J.1, Author
Beiser, Alexa1, Author
Bey, Katharina1, Author
Bis, Joshua C.1, Author
Boerwinkle, Eric1, Author
Bressler, Jan1, Author
Campbell, Archie1, Author
Campbell, Harry1, Author
Chen, Qiang1, Author
Corley, Janie1, Author
Cox, Simon R.1, Author
Davies, Gail1, Author
De Jager, Philip L.1, Author
Derks, Eske M.1, Author
Faul, Jessica D.1, AuthorFitzpatrick, Annette L.1, AuthorFohner, Alison E.1, AuthorFord, Ian1, AuthorFornage, Myriam1, AuthorGerring, Zachary1, AuthorGrabe, Hans J.1, AuthorGrodstein, Francine1, AuthorGudnason, Vilmundur1, AuthorSimonsick, Eleanor1, AuthorHolliday, Elizabeth G.1, AuthorJoshi, Peter K.1, AuthorKajantie, Eero1, AuthorKaprio, Jaakko1, AuthorKarell, Pauliina1, AuthorKleineidam, Luca1, AuthorKnol, Maria J.1, AuthorKochan, Nicole A.1, AuthorKwok, John B.1, AuthorLeber, Markus1, AuthorLam, Max1, AuthorLee, Teresa1, AuthorLi, Shuo1, AuthorLoukola, Anu1, AuthorLuck, Tobias1, AuthorMarioni, Riccardo E.1, AuthorMather, Karen A.1, AuthorMedland, Sarah1, AuthorMirza, Saira S.1, AuthorNalls, Mike A.1, AuthorNho, Kwangsik1, AuthorO’Donnell, Adrienne1, AuthorOldmeadow, Christopher1, AuthorPainter, Jodie1, AuthorPattie, Alison1, AuthorReppermund, Simone1, AuthorRisacher, Shannon L.1, AuthorRose, Richard J.1, AuthorSadashivaiah, Vijay1, AuthorScholz, Markus1, AuthorSatizabal, Claudia L.1, AuthorSchofield, Peter W.1, AuthorSchraut, Katharina E.1, AuthorScott, Rodney J.1, AuthorSimino, Jeannette1, AuthorSmith, Albert V.1, AuthorSmith, Jennifer A.1, AuthorStott, David J.1, AuthorSurakka, Ida1, AuthorTeumer, Alexander1, AuthorThalamuthu, Anbupalam1, AuthorTrompet, Stella1, AuthorTurner, Stephen T.1, Authorvan der Lee, Sven J.1, AuthorVillringer, Arno2, Author           Völker, Uwe1, AuthorWilson, Robert S.1, AuthorWittfeld, Katharina1, AuthorVuoksimaa, Eero1, AuthorXia, Rui1, AuthorYaffe, Kristine1, AuthorYu, Lei1, AuthorZare, Habil1, AuthorZhao, Wei1, AuthorAmes, David1, AuthorAttia, John1, AuthorBennett, David A.1, AuthorBrodaty, Henry1, AuthorChasman, Daniel I.1, AuthorGoldman, Aaron L.1, AuthorHayward, Caroline1, AuthorIkram, M. Arfan1, AuthorJukema, J. Wouter1, AuthorKardia, Sharon L. R.1, AuthorLencz, Todd1, AuthorLoeffler, Markus1, AuthorMattay, Venkata S.1, AuthorPalotie, Aarno1, AuthorPsaty, Bruce M.1, AuthorRamirez, Alfredo1, AuthorRidker, Paul M.1, AuthorRiedel-Heller, Steffi G.1, AuthorSachdev, Perminder S.1, AuthorSaykin, Andrew J.1, AuthorScherer, Martin1, AuthorSchofield, Peter R.1, AuthorSidney, Stephen1, AuthorStarr, John M.1, AuthorTrollor, Julian1, AuthorUlrich, William1, AuthorWagner, Michael1, AuthorWeir, David R.1, AuthorWilson, James F.1, AuthorWright, Margaret J.1, AuthorWeinberger, Daniel R.1, AuthorDebette, Stephanie1, AuthorEriksson, Johan G.1, AuthorMosley, Thomas H.1, AuthorLauner, Lenore J.1, Authorvan Duijn, Cornelia M.1, AuthorDeary, Ian J.1, AuthorSeshadri, Sudha1, AuthorRäikkönen, Katri1, Author more..
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1External Organizations, ou_persistent22              
2Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              

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Free keywords: Genetics; Neuroscience
 Abstract: Understanding the genomic basis of memory processes may help in combating neurodegenerative disorders. Hence, we examined the associations of common genetic variants with verbal short-term memory and verbal learning in adults without dementia or stroke (N = 53,637). We identified novel loci in the intronic region of CDH18, and at 13q21 and 3p21.1, as well as an expected signal in the APOE/APOC1/TOMM40 region. These results replicated in an independent sample. Functional and bioinformatic analyses supported many of these loci and further implicated POC1. We showed that polygenic score for verbal learning associated with brain activation in right parieto-occipital region during working memory task. Finally, we showed genetic correlations of these memory traits with several neurocognitive and health outcomes. Our findings suggest a role of several genomic loci in verbal memory processes.

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Language(s): eng - English
 Dates: 2022-07-112020-07-142022-07-132022-08-16
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1038/s41380-022-01710-8
Other: online ahead of print
PMID: 35974141
 Degree: -

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Title: Molecular Psychiatry
Source Genre: Journal
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Publ. Info: Houndmills, Hampshire, UK : Stockton Press
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 1359-4184
CoNE: https://pure.mpg.de/cone/journals/resource/954925619131