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  Rate and oscillatory switching dynamics of a multilayer visual microcircuit model

Hahn, G., Kumar, A., Schmidt, H., Knösche, T. R., & Deco, G. (2022). Rate and oscillatory switching dynamics of a multilayer visual microcircuit model. eLife, 11: e77594. doi:10.7554/eLife.77594.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000A-F1BE-0 Version Permalink: https://hdl.handle.net/21.11116/0000-000E-522B-6
Genre: Journal Article

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 Creators:
Hahn, Gerald1, Author
Kumar, Arvind2, Author
Schmidt, Helmut3, Author           
Knösche, Thomas R.3, 4, Author           
Deco, Gustavo1, 5, 6, 7, Author           
Affiliations:
1Computational Neuroscience Group, Department of Information and Communication Technologies, Center for Brain and Cognition, University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
2Division of Computational Science and Technology, KTH Royal Institute of Technology, Stockholm, Sweden, ou_persistent22              
3Methods and Development Group Brain Networks, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205650              
4Institute for Biomedical Engineering and Informatics, TU Ilmenau, Germany, ou_persistent22              
5Catalan Institution for Research and Advanced Studies (ICREA), University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
6Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
7School of Psychological Sciences, Monash University, Melbourne, Australia, ou_persistent22              

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Free keywords: Cortical layers; Microcircuit; Modeling; Mouse; Neuroscience; Oscillations; Switching dynamics
 Abstract: The neocortex is organized around layered microcircuits consisting of a variety of excitatory and inhibitory neuronal types which perform rate- and oscillation-based computations. Using modeling, we show that both superficial and deep layers of the primary mouse visual cortex implement two ultrasensitive and bistable switches built on mutual inhibitory connectivity motives between somatostatin, parvalbumin, and vasoactive intestinal polypeptide cells. The switches toggle pyramidal neurons between high and low firing rate states that are synchronized across layers through translaminar connectivity. Moreover, inhibited and disinhibited states are characterized by low- and high-frequency oscillations, respectively, with layer-specific differences in frequency and power which show asymmetric changes during state transitions. These findings are consistent with a number of experimental observations and embed firing rate together with oscillatory changes within a switch interpretation of the microcircuit.

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Language(s): eng - English
 Dates: 2022-02-042022-07-212022-08-22
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.7554/eLife.77594
PMID: 35994330
PMC: PMC9395191
 Degree: -

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Project name : -
Grant ID : 720270; 785907; 661583
Funding program : Horizon 2020
Funding organization : European Union
Project name : -
Grant ID : 2017 SGR 1545
Funding program : Catalan AGAUR program
Funding organization : -
Project name : -
Grant ID : KN 588/7-1
Funding program : -
Funding organization : German Research Council (DFG)
Project name : Spanish Research Project COBRAS
Grant ID : PSI2016-75688-P
Funding program : -
Funding organization : -
Project name : -
Grant ID : -
Funding program : -
Funding organization : Swedish Research Council
Project name : -
Grant ID : -
Funding program : -
Funding organization : Max Planck Institute for Human Cognitive and Brain Sciences
Project name : -
Grant ID : PID2019-105772GB-I00 /AEI/10.13039/501100011033
Funding program : -
Funding organization : Spanish Ministry of Science, Innovation and Universities

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Title: eLife
Source Genre: Journal
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Publ. Info: Cambridge : eLife Sciences Publications
Pages: - Volume / Issue: 11 Sequence Number: e77594 Start / End Page: - Identifier: ISSN: 2050-084X
CoNE: https://pure.mpg.de/cone/journals/resource/2050-084X