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  Enzymatically active biomimetic micropropellers for the penetration of mucin gels

Walker (Schamel), D., Käsdorf, B. T., Jeong, H. H., Lieleg, O., & Fischer, P. (2015). Enzymatically active biomimetic micropropellers for the penetration of mucin gels. Science Advances, 1(11): e1500501, pp. 1-7. doi:10.1126/sciadv.1500501.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000B-0CFB-E Version Permalink: https://hdl.handle.net/21.11116/0000-000E-4B2D-D
Genre: Journal Article

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 Creators:
Walker (Schamel), Debora, Author
Käsdorf, Benjamin T., Author
Jeong, H. H., Author
Lieleg, Oliver, Author
Fischer, Peer1, Author                 
Affiliations:
1Max Planck Institute for Medical Research, Max Planck Society, ou_1125545              

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Free keywords: Micropropellers; biomimetic penetration of biological gels; gastric mucus barrier; gel-sol transition; helicobacter pylori swimming mechanism; muco-adhesion; propulsion in viscoelastic media; urease surface immobilization
 Abstract: In the body, mucus provides an important defense mechanism by limiting the penetration of pathogens. It is therefore also a major obstacle for the efficient delivery of particle-based drug carriers. The acidic stomach lining in particular is difficult to overcome because mucin glycoproteins form viscoelastic gels under acidic conditions. The bacterium Helicobacter pylori has developed a strategy to overcome the mucus barrier by producing the enzyme urease, which locally raises the pH and consequently liquefies the mucus. This allows the bacteria to swim through mucus and to reach the epithelial surface. We present an artificial system of reactive magnetic micropropellers that mimic this strategy to move through gastric mucin gels by making use of surface-immobilized urease. The results demonstrate the validity of this biomimetic approach to penetrate biological gels, and show that externally propelled microstructures can actively and reversibly manipulate the physical state of their surroundings, suggesting that such particles could potentially penetrate native mucus.

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Language(s): eng - English
 Dates: 2015-04-212015-09-252015-12-11
 Publication Status: Issued
 Pages: 8
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1126/sciadv.1500501
BibTex Citekey: 2015walker
URI: https://pubmed.ncbi.nlm.nih.gov/26824056/
 Degree: -

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Title: Science Advances
  Other : Sci. Adv.
Source Genre: Journal
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Publ. Info: Washington : AAAS
Pages: - Volume / Issue: 1 (11) Sequence Number: e1500501 Start / End Page: 1 - 7 Identifier: ISSN: 2375-2548
CoNE: https://pure.mpg.de/cone/journals/resource/2375-2548