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  Drosophila ankyrin 2 is required for synaptic stability

Koch, I., Schwarz, H., Beuchle, D., Goellner, B., Langegger, M., & Aberle, H. (2008). Drosophila ankyrin 2 is required for synaptic stability. Neuron, 58(2), 210-222. doi:10.1016/j.neuron.2008.03.019.

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 Creators:
Koch, I, Author           
Schwarz, H, Author           
Beuchle, D, Author           
Goellner, B, Author
Langegger, M1, Author           
Aberle, H, Author           
Affiliations:
1Hauf Group, Friedrich Miescher Laboratory, Max Planck Society, ou_3377924              

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 Abstract: Synaptic connections are stabilized through transsynaptic adhesion complexes that are anchored in the underlying cytoskeleton. The Drosophila neuromuscular junction (NMJs) serves as a model system to unravel genes required for the structural remodeling of synapses. In a mutagenesis screen for regulators of synaptic stability, we recovered mutations in Drosophila ankyrin 2 (ank2) affecting two giant Ank2 isoforms that are specifically expressed in the nervous system and associate with the presynaptic membrane cytoskeleton. ank2 mutant larvae show severe deficits in the stability of NMJs, resulting in a reduction in overall terminal size, withdrawal of synaptic boutons, and disassembly of presynaptic active zones. In addition, lack of Ank2 leads to disintegration of the synaptic microtubule cytoskeleton. Microtubules and microtubule-associated proteins fail to extend into distant boutons. Interestingly, Ank2 functions downstream of spectrin in the anchorage of synaptic microtubules, providing the cytoskeletal scaffold that is essential for synaptic stability.

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 Dates: 2008-04
 Publication Status: Issued
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 Rev. Type: -
 Identifiers: DOI: 10.1016/j.neuron.2008.03.019
PMID: 18439406
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Title: Neuron
Source Genre: Journal
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Publ. Info: Cambridge, Mass. : Cell Press
Pages: - Volume / Issue: 58 (2) Sequence Number: - Start / End Page: 210 - 222 Identifier: ISSN: 0896-6273
CoNE: https://pure.mpg.de/cone/journals/resource/954925560565