English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
 
 
DownloadE-Mail
  No evidence for age-related alterations in the marmoset retina

Haverkamp, S., Reinhard, K., Peichl, L., & Mietsch, M. (2022). No evidence for age-related alterations in the marmoset retina. Frontiers in Neuroanatomy, 16: 945295. doi:10.3389/fnana.2022.945295.

Item is

Files

show Files
hide Files
:
fnana-16-945295.pdf (Publisher version), 9MB
Name:
fnana-16-945295.pdf
Description:
-
OA-Status:
Not specified
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
2022
Copyright Info:
© 2022 Haverkamp, Reinhard, Peichl and Mietsch.
:
Data_Sheet_1_No evidence for age-related alterations in the marmoset retina.docx (Supplementary material), 387KB
Name:
Data_Sheet_1_No evidence for age-related alterations in the marmoset retina.docx
Description:
-
OA-Status:
Not specified
Visibility:
Public
MIME-Type / Checksum:
application/vnd.openxmlformats-officedocument.wordprocessingml.document / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show
hide
Description:
Original Research article
OA-Status:
Not specified

Creators

show
hide
 Creators:
Haverkamp, Silke1, Author                 
Reinhard, Katja2, Author
Peichl, Leo2, Author
Mietsch, Matthias2, Author
Affiliations:
1Department of Computational Neuroethology, Max Planck Institute for Neurobiology of Behavior – caesar, Max Planck Society, ou_3361762              
2External Organizations, ou_persistent22              

Content

show
hide
Free keywords: -
 Abstract: The physiological aging process of the retina is accompanied by various and sometimes extensive changes: Macular degeneration, retinopathies and glaucoma are the most common findings in the elderly and can potentially lead to irreversible visual disablements up to blindness. To study the aging process and to identify possible therapeutic targets to counteract these diseases, the use of appropriate animal models is mandatory. Besides the most commonly used rodent species, a non-human primate, the common marmoset (Callithrix jacchus) emerged as a promising animal model of human aging over the last years. However, the visual aging process in this species is only partially characterized, especially with regard to retinal aberrations. Therefore, we assessed here for the first time potential changes in retinal morphology of the common marmoset of different age groups. By cell type specific immunolabeling, we analyzed different cell types and distributions, potential photoreceptor and ganglion cell loss, and structural reorganization. We detected no signs of age-related differences in staining patterns or densities of various cell populations. For example, there were no signs of photoreceptor degeneration, and there was only minimal sprouting of rod bipolar cells in aged retinas. Altogether, we describe here the maintenance of a stable neuronal architecture, distribution and number of different cell populations with only mild aberrations during the aging process in the common marmoset retina. These findings are in stark contrast to previously reported findings in rodent species and humans and deserve further investigations to identify the underlying mechanisms and possible therapeutic targets.

Details

show
hide
Language(s): eng - English
 Dates: 2022-09-02
 Publication Status: Published online
 Pages: 16
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.3389/fnana.2022.945295
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Frontiers in Neuroanatomy
  Abbreviation : Front Neuroanat
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Lausanne, Switzerland : Frontiers Research Foundation
Pages: - Volume / Issue: 16 Sequence Number: 945295 Start / End Page: - Identifier: ISSN: 1662-5129
CoNE: https://pure.mpg.de/cone/journals/resource/1662-5129