English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
 
 
DownloadE-Mail
  Unbiased retrieval of frequency-dependent mechanical properties from noisy time-dependent signals

Abuhattum, S., Kuan, H.-S., Mueller, P., Guck, J., & Zaburdaev, V. (2022). Unbiased retrieval of frequency-dependent mechanical properties from noisy time-dependent signals. Biophysical Reports, 2(3): 100054. doi:10.1016/j.bpr.2022.100054.

Item is

Files

show Files
hide Files
:
Biophys Rep 2022 Abuhattum.pdf (Publisher version), 941KB
Name:
Biophys Rep 2022 Abuhattum.pdf
Description:
-
OA-Status:
Not specified
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
This is an open access article under the CC BY license

Locators

show

Creators

show
hide
 Creators:
Abuhattum, Shada1, 2, 3, Author           
Kuan, Hui-Shun3, 4, Author
Mueller, Paul1, 2, 3, Author           
Guck, Jochen1, 2, 3, 5, Author           
Zaburdaev, Vasily2, 4, Author
Affiliations:
1Guck Division, Max Planck Institute for the Science of Light, Max Planck Society, ou_3164416              
2Max-Planck-Zentrum für Physik und Medizin, Max Planck Institute for the Science of Light, Max Planck Society, ou_3164414              
3external, ou_persistent22              
4Friedrich-Alexander-Universität Erlangen-Nürnberg, Department Biologie, ou_persistent22              
5Friedrich-Alexander-Universität Erlangen-Nürnberg, Department Physik, ou_persistent22              

Content

show
hide
Free keywords: -
 Abstract: The mechanical response of materials to dynamic loading is often quantified by the frequency-dependent complex modulus. Probing materials directly in the frequency domain faces technical challenges such as a limited range of frequencies, long measurement times, or small sample sizes. Furthermore, many biological samples, such as cells or tissues, can change their properties upon repetitive probing at different frequencies. Therefore, it is common practice to extract the material properties by fitting predefined mechanical models to measurements performed in the time domain. This practice, however, precludes the probing of unique and yet unexplored material properties. In this report, we demonstrate that the frequency-dependent complex modulus can be robustly retrieved in a model-independent manner directly from time-dependent stress-strain measurements. While applying a rolling average eliminates random noise and leads to a reliable complex modulus in the lower frequency range, a Fourier transform with a complex frequency helps to recover the material properties at high frequencies. Finally, by properly designing the probing procedure, the recovery of reliable mechanical properties can be extended to an even wider frequency range. Our approach can be used with many state-of-the-art experimental methods to interrogate the mechanical properties of biological and other complex materials.

Details

show
hide
Language(s): eng - English
 Dates: 2022-03-242022-03-30
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/j.bpr.2022.100054
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Biophysical Reports
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 2 (3) Sequence Number: 100054 Start / End Page: - Identifier: ISSN: 2667-0747