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  Quantitative phase imaging through an ultra-thin lensless fiber endoscope

Sun, J., Wu, J., Goswami, R., Girardo, S., Cao, L., Guck, J., et al. (2022). Quantitative phase imaging through an ultra-thin lensless fiber endoscope. Light: Science & Applications, 11: 204. doi:10.1038/s41377-022-00898-2.

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Datensatz-Permalink: https://hdl.handle.net/21.11116/0000-000A-FF32-F Versions-Permalink: https://hdl.handle.net/21.11116/0000-000F-9D9A-3
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Light Sci Appl 2022 Sun.pdf (Verlagsversion), 3MB
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Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any mediumor format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changesweremade. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license,
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 Urheber:
Sun, Jiawei1, Autor
Wu, Jiachen1, 2, Autor
Goswami, Ruchi3, Autor           
Girardo, Salvatore3, Autor           
Cao, Liangcai2, Autor
Guck, Jochen1, 3, 4, Autor           
Koukourakis, Nektarios1, Autor
Czarske, Jürgen W.1, Autor
Affiliations:
1Technische Universität Dresden, ou_persistent22              
2external, ou_persistent22              
3Guck Division, Max Planck Institute for the Science of Light, Max Planck Society, ou_3164416              
4Guck Division, Max-Planck-Zentrum für Physik und Medizin, Max Planck Institute for the Science of Light, Max Planck Society, ou_3596668              

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 Zusammenfassung: Quantitative phase imaging (QPI) is a label-free technique providing both morphology and quantitative biophysical information in biomedicine. However, applying such a powerful technique to in vivo pathological diagnosis remains challenging. Multi-core fiber bundles (MCFs) enable ultra-thin probes for in vivo imaging, but current MCF imaging techniques are limited to amplitude imaging modalities. We demonstrate a computational lensless microendoscope that uses an ultra-thin bare MCF to perform quantitative phase imaging with microscale lateral resolution and nanoscale axial sensitivity of the optical path length. The incident complex light field at the measurement side is precisely reconstructed from the far-field speckle pattern at the detection side, enabling digital refocusing in a multi-layer sample without any mechanical movement. The accuracy of the quantitative phase reconstruction is validated by imaging the phase target and hydrogel beads through the MCF. With the proposed imaging modality, three-dimensional imaging of human cancer cells is achieved through the ultra-thin fiber endoscope, promising widespread clinical applications.

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Sprache(n): eng - English
 Datum: 2022-06-162022-07-05
 Publikationsstatus: Erschienen
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 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: DOI: 10.1038/s41377-022-00898-2
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Titel: Light: Science & Applications
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: London : Nature Publ. Group
Seiten: - Band / Heft: 11 Artikelnummer: 204 Start- / Endseite: - Identifikator: ISSN: 2047-7538
CoNE: https://pure.mpg.de/cone/journals/resource/2047-7538