English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
 
 
DownloadE-Mail
  The pax-3 gene is involved in vulva formation in Pristionchus pacificus and is a target of the Hox gene lin-39

Yi, B., & Sommer, R. (2007). The pax-3 gene is involved in vulva formation in Pristionchus pacificus and is a target of the Hox gene lin-39. Development, 134(17), 3111-3119. doi:10.1242/dev.008375.

Item is

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Yi, B1, Author           
Sommer, RJ1, Author                 
Affiliations:
1Department Integrative Evolutionary Biology, Max Planck Institute for Developmental Biology, Max Planck Society, ou_3375786              

Content

show
hide
Free keywords: -
 Abstract: The Hox gene lin-39 plays a crucial role in the establishment of the nematode vulva equivalence group. Mutations in lin-39 in Caenorhabditis elegans and Pristionchus pacificus result in a vulvaless phenotype because presumptive vulva precursor cells adopt non-vulval fates. Interestingly, the non-vulval fate of anterior and posterior epidermal cells differs between Caenorhabditis and Pristionchus; in C. elegans, non-vulval cells fuse with the hypodermis, whereas, in P. pacificus, they die as a result of programmed cell death. C. elegans lin-39 (Cel-lin-39) indirectly controls the cell fusion gene eff-1 by regulating the GATA transcription factors egl-18 and elt-6. In P. pacificus, the genetic context of its lin-39 (Ppa-lin-39) function was unknown. Here, we describe the isolation and characterization of gev-2, a second generation-vulvaless mutant in P. pacificus. We show that gev-2 is the Ppa-pax-3 gene and that it has distinct functions in the cell fate specification of epidermal cells. Whereas Ppa-pax-3 regulates cell survival of the presumptive vulval precursor cells, it controls cell death of posterior epidermal cells. Molecular studies indicate that Ppa-pax-3 is a direct target of Ppa-LIN-39. Thus, we describe the first specific developmental defect of a nematode pax-3 gene and our data reveal different regulatory networks for the specification of the vulva equivalence group.

Details

show
hide
Language(s):
 Dates: 2007-09
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1242/dev.008375
PMID: 17652349
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Development
  Other : Development
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Cambridge, Cambridgeshire : Company of Biologists
Pages: - Volume / Issue: 134 (17) Sequence Number: - Start / End Page: 3111 - 3119 Identifier: ISSN: 0950-1991
CoNE: https://pure.mpg.de/cone/journals/resource/954927546241