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  SARS-CoV-2 Infects Red Blood Cell Progenitors and Dysregulates Hemoglobin and Iron Metabolism.

Kronstein-Wiedemann, R., Stadtmüller, M., Traikov, S., Georgi, M., Teichert, M., Yosef, H., et al. (2022). SARS-CoV-2 Infects Red Blood Cell Progenitors and Dysregulates Hemoglobin and Iron Metabolism. Stem cell reviews and reports, 18(5), 1809-1821. doi:10.1007/s12015-021-10322-8.

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 Creators:
Kronstein-Wiedemann, Romy, Author
Stadtmüller, Marlena, Author
Traikov, Sofia1, Author           
Georgi, Mandy, Author
Teichert, Madeleine, Author
Yosef, Hesham, Author
Wallenborn, Jan, Author
Karl, Andreas, Author
Schütze, Karin, Author
Wagner, Michael, Author
El-Armouche, A, Author
Tonn, Torsten, Author
Affiliations:
1Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society, ou_2340692              

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 Abstract: SARS-CoV-2 infection causes acute respiratory distress, which may progress to multiorgan failure and death. Severe COVID-19 disease is accompanied by reduced erythrocyte turnover, low hemoglobin levels along with increased total bilirubin and ferritin serum concentrations. Moreover, expansion of erythroid progenitors in peripheral blood together with hypoxia, anemia, and coagulopathies highly correlates with severity and mortality. We demonstrate that SARS-CoV-2 directly infects erythroid precursor cells, impairs hemoglobin homeostasis and aggravates COVID-19 disease.

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 Dates: 2022-06-01
 Publication Status: Issued
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 Rev. Type: -
 Identifiers: DOI: 10.1007/s12015-021-10322-8
Other: cbg-8317
PMID: 35181867
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Title: Stem cell reviews and reports
  Other : Stem Cell Rev Rep
Source Genre: Journal
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Pages: - Volume / Issue: 18 (5) Sequence Number: - Start / End Page: 1809 - 1821 Identifier: -