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  Tig1 regulates proximo-distal identity during salamander limb regeneration.

Oliveira, C., Knapp, D., Elewa, A., Gerber, T., Malagon, S. G. G., Gates, P. B., et al. (2022). Tig1 regulates proximo-distal identity during salamander limb regeneration. Nature communications, 13(1): 1141. doi:10.1038/s41467-022-28755-1.

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Oliveira, Catarina1, Autor           
Knapp, Dunja1, Autor           
Elewa, Ahmed, Autor
Gerber, Tobias, Autor
Malagon, Sandra G Gonzalez, Autor
Gates, Phillip B, Autor
Walters, Hannah E, Autor
Petzold, Andreas, Autor
Arce, Hernan, Autor
Cordoba, Rodrigo C, Autor
Subramanian, Elaiyaraja, Autor
Chara, Osvaldo, Autor
Tanaka, Elly M.1, Autor           
Simon, András, Autor
Yun, Maximina H1, Autor           
Affiliations:
1Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society, ou_2340692              

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 Zusammenfassung: Salamander limb regeneration is an accurate process which gives rise exclusively to the missing structures, irrespective of the amputation level. This suggests that cells in the stump have an awareness of their spatial location, a property termed positional identity. Little is known about how positional identity is encoded, in salamanders or other biological systems. Through single-cell RNAseq analysis, we identified Tig1/Rarres1 as a potential determinant of proximal identity. Tig1 encodes a conserved cell surface molecule, is regulated by retinoic acid and exhibits a graded expression along the proximo-distal axis of the limb. Its overexpression leads to regeneration defects in the distal elements and elicits proximal displacement of blastema cells, while its neutralisation blocks proximo-distal cell surface interactions. Critically, Tig1 reprogrammes distal cells to a proximal identity, upregulating Prod1 and inhibiting Hoxa13 and distal transcriptional networks. Thus, Tig1 is a central cell surface determinant of proximal identity in the salamander limb.

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 Datum: 2022-03-03
 Publikationsstatus: Erschienen
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 Identifikatoren: DOI: 10.1038/s41467-022-28755-1
Anderer: cbg-8320
PMID: 35241664
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Titel: Nature communications
  Andere : Nat Commun
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 13 (1) Artikelnummer: 1141 Start- / Endseite: - Identifikator: -