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Abstract:
Nematodes provide a useful experimental system with which to investigate the evolution of development at the cellular, genetic, and molecular levels. Building on an understanding of vulval development in Caenorhabditis elegans, analysis of vulval development has been extended to a number of other species in three families of the Nematode phylum. Changes have occurred in most aspects of vulval development: alteration in the number of cells competent to participate in vulval development by changes in apoptosis; changes in the relative contributions of position-dependent predisposition toward particular fates (prepattern), inductive signaling and lateral signaling; and in the specific lineages generated by vulval precursor cells. Genetic analysis of one species in which only three vulval precursor cells are present identified a mutation that increases the number of vulva precursor cells toward that found in C. elegans.
