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  Micro- and nanopatterned substrates for studies on the mechanobiology of cell–matrix adhesions

Christian, J., & Cavalcanti-Adam, E. A. (2022). Micro- and nanopatterned substrates for studies on the mechanobiology of cell–matrix adhesions. In J. Nakanishi, & K. Uto (Eds.), Material-based Mechanobiology (pp. 135-151). Cambridge: Royal Society of Chemistry.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000B-0BFD-D Version Permalink: https://hdl.handle.net/21.11116/0000-000B-B656-7
Genre: Book Chapter

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Nakanishi_2022_Material-based Mechanobiol_135.pdf (Any fulltext), 14MB
 
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https://pubs.rsc.org/en/content/chapter/bk9781839161858-00135/978-1-83916-185-8 (Any fulltext)
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 Creators:
Christian, Joel1, Author           
Cavalcanti-Adam, Elisabetta Ada1, Author           
Affiliations:
1Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_2364731              

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 Abstract: The cell microenvironment acts as an adhesive and signaling platform for cells, where both chemical and physical signals are integrated to trigger cell functions. Materials that recapitulate such features of the extracellular space are inspired by the composition and structure of the extracellular matrix. A great effort over the past decades has been directed to achieving micro- and nanoscale precision in mimicking the extracellular matrix spatial organization, while combining it with the presentation of specific ligands to study receptor behavior and signaling cascades. In this chapter, we outline materials-based strategies combined with mechanobiological approaches for patterning extracellular molecules and ligands and describe how their spatial presentation allows us to address mechanosensing and mechanotransduction in cells.

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Language(s): eng - English
 Dates: 2022
 Publication Status: Issued
 Pages: 17
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1039/9781839165375-00135
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Title: Material-based Mechanobiology
Source Genre: Book
 Creator(s):
Nakanishi, Jun, Editor
Uto, Koichiro, Editor
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Publ. Info: Cambridge : Royal Society of Chemistry
Pages: 350 Volume / Issue: - Sequence Number: - Start / End Page: 135 - 151 Identifier: ISBN: 978-1-83916-185-8

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Title: Biomaterials Science Series
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Publ. Info: Cambridge : Royal Society of Chemistry
Pages: - Volume / Issue: 12 Sequence Number: - Start / End Page: - Identifier: ISSN: 2397-1401