English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Measuring arterial pulsatility with dynamic inflow magnitude contrast

Whittaker, J., Fasano, F., Venzi, M., Liebig, P., Gallichan, D., Möller, H. E., et al. (2022). Measuring arterial pulsatility with dynamic inflow magnitude contrast. Frontiers in Neuroscience, 15: 795749. doi:10.3389/fnins.2021.795749.

Item is

Files

show Files
hide Files
:
Whittaker_Fasano_2022.pdf (Publisher version), 5MB
Name:
Whittaker_Fasano_2022.pdf
Description:
-
OA-Status:
Gold
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Whittaker, Joseph1, 2, Author           
Fasano, Fabrizio3, Author
Venzi, Marcello1, Author
Liebig, Patrick4, Author
Gallichan, Daniel5, Author
Möller, Harald E.2, Author           
Murphy, Kevin1, Author
Affiliations:
1Brain Research Imaging Centre, School of Physics and Astronomy, Cardiff University, United Kingdom, ou_persistent22              
2Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
3Siemens Healthineers, Camberley, United Kingdom, ou_persistent22              
4Siemens Healthcare GmbH, Erlangen, Germany, ou_persistent22              
5Brain Research Imaging Centre, School of Engineering, Cardiff University, United Kingdom, ou_persistent22              

Content

show
hide
Free keywords: Magnetic resonance imaging (MRI); Pulsatility; Cerebral arteries; Echo-planar imaging (EPI); Arterial stiffness; Inflow effect; Cerebral blood flow velocity
 Abstract: The pulsatility of blood flow through cerebral arteries is clinically important, as it is intrinsically associated with cerebrovascular health. In this study we outline a new MRI approach to measuring the real-time pulsatile flow in cerebral arteries, which is based on the inflow phenomenon associated with fast gradient-recalled-echo acquisitions. Unlike traditional phase-contrast techniques, this new method, which we dub dynamic inflow magnitude contrast (DIMAC), does not require velocity-encoding gradients as sensitivity to flow velocity is derived purely from the inflow effect. We achieved this using a highly accelerated single slice EPI acquisition with a very short TR (15 ms) and a 90° flip angle, thus maximizing inflow contrast. We simulate the spoiled GRE signal in the presence of large arteries and perform a sensitivity analysis. The sensitivity analysis demonstrates that in the regime of high inflow contrast, DIMAC shows much greater sensitivity to flow velocity over blood volume changes. We support this theoretical prediction with in-vivo data collected in two separate experiments designed to demonstrate the utility of the DIMAC signal contrast. We perform a hypercapnia challenge experiment in order to experimentally modulate arterial tone within subjects, and thus modulate the arterial pulsatile flow waveform. We also perform a thigh-cuff release challenge, designed to induce a transient drop in blood pressure, and demonstrate that the continuous DIMAC signal captures the complex transient change in the pulsatile and non-pulsatile components of flow. In summary, this study proposes a new role for a well-established source of MR image contrast and demonstrates its potential for measuring both steady-state and dynamic changes in arterial tone.

Details

show
hide
Language(s): eng - English
 Dates: 2021-10-152021-12-222022-01-17
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.3389/fnins.2021.795749
Other: eCollection 2021
PMID: 35110991
PMC: PMC8802674
 Degree: -

Event

show

Legal Case

show

Project information

show hide
Project name : -
Grant ID : WT200804
Funding program : -
Funding organization : Wellcome Trust

Source 1

show
hide
Title: Frontiers in Neuroscience
  Other : Front Neurosci
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Lausanne, Switzerland : Frontiers Research Foundation
Pages: - Volume / Issue: 15 Sequence Number: 795749 Start / End Page: - Identifier: ISSN: 1662-4548
ISSN: 1662-453X
CoNE: https://pure.mpg.de/cone/journals/resource/1662-4548