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  Enhancing neuroimaging genetics through meta-analysis for Tourette syndrome (ENIGMA-TS): A worldwide platform for collaboration

Paschou, P., Jin, Y., Müller-Vahl, K., Möller, H. E., Rizzo, R., Hoekstra, P. J., et al. (2022). Enhancing neuroimaging genetics through meta-analysis for Tourette syndrome (ENIGMA-TS): A worldwide platform for collaboration. Frontiers in Psychiatry, 13: 958688. doi:10.3389/fpsyt.2022.958688.

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Paschou, Peristera1, Author
Jin, Yin1, Author
Müller-Vahl, Kirsten1, Author
Möller, Harald E.2, Author           
Rizzo, Renata1, Author
Hoekstra, Pieter J.1, Author
Roessner, Veit1, Author
Mol Debes, Nanette1, Author
Worbe, Yulia1, Author
Hartmann, Andreas1, Author
Mir, Pablo1, Author
Cath, Danielle1, Author
Neuner, Irene1, Author
Eichele, Heike1, Author
Zhang, Chencheng1, Author
Lewandowska, Katarzyna1, Author
Munchau, Alexander1, Author
Verrel, Julius1, Author
Musil, Richard1, Author
Silk, Tim J.1, Author
Hanlon, Colleen A.1, AuthorBihun, Emily D.1, AuthorBrandt, Valerie1, AuthorDietrich, Andrea1, AuthorForde, Natalie1, AuthorGanos, Christos1, AuthorGreene, Deanna J.1, AuthorChu, Chunguang1, AuthorGrothe, Michel J.1, AuthorHershey, Tamara1, AuthorJanik, Piotr1, AuthorKoller, Jonathan M.1, AuthorMartin-Rodriguez, Juan Francisco1, AuthorMueller, Karsten2, 3, Author           Palmucci, Stefano1, AuthorPrato, Adriana1, AuthorRamkiran, Shukti1, AuthorSaia, Federica1, AuthorSzejko, Natalia1, AuthorTorrecuso, Renzo2, Author           Tumer, Zeynep1, AuthorUhlmann, Anne1, AuthorVeselinovic, Tanja1, AuthorWolańczyk, Tomasz1, AuthorZouki, Jade-Jocelyne1, AuthorJain, Pritesh1, AuthorTopaloudi, Apostolia1, AuthorKaka, Mary1, AuthorYang, Zhiyu1, AuthorDrineas, Petros1, AuthorThomopoulos, Sophia I.1, AuthorWhite, Tonya1, AuthorVeltman, Dick J.1, AuthorSchmaal, Lianne1, AuthorStein, Dan J.1, AuthorBuitelaar, Jan1, AuthorFranke, Barbara1, Authorvan den Heuvel, Odile1, AuthorJahanshad, Neda1, AuthorThompson, Paul M.1, AuthorBlack, Kevin J.1, Author more..
1External Organizations, ou_persistent22              
2Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
3Method and Development Group Neural Data Science and Statistical Computing, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_3282987              


Free keywords: ENIGMA; Tourette syndrome; Brain MRI; Genetics; Neuroimaging
 Abstract: Tourette syndrome (TS) is characterized by multiple motor and vocal tics, and high-comorbidity rates with other neuropsychiatric disorders. Obsessive compulsive disorder (OCD), attention deficit hyperactivity disorder (ADHD), autism spectrum disorders (ASDs), major depressive disorder (MDD), and anxiety disorders (AXDs) are among the most prevalent TS comorbidities. To date, studies on TS brain structure and function have been limited in size with efforts mostly fragmented. This leads to low-statistical power, discordant results due to differences in approaches, and hinders the ability to stratify patients according to clinical parameters and investigate comorbidity patterns. Here, we present the scientific premise, perspectives, and key goals that have motivated the establishment of the Enhancing Neuroimaging Genetics through Meta-Analysis for TS (ENIGMA-TS) working group. The ENIGMA-TS working group is an international collaborative effort bringing together a large network of investigators who aim to understand brain structure and function in TS and dissect the underlying neurobiology that leads to observed comorbidity patterns and clinical heterogeneity. Previously collected TS neuroimaging data will be analyzed jointly and integrated with TS genomic data, as well as equivalently large and already existing studies of highly comorbid OCD, ADHD, ASD, MDD, and AXD. Our work highlights the power of collaborative efforts and transdiagnostic approaches, and points to the existence of different TS subtypes. ENIGMA-TS will offer large-scale, high-powered studies that will lead to important insights toward understanding brain structure and function and genetic effects in TS and related disorders, and the identification of biomarkers that could help inform improved clinical practice.


Language(s): eng - English
 Dates: 2022-08-18
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.3389/fpsyt.2022.958688
Other: eCollection 2022
PMID: 36072455
PMC: PMC9443935
 Degree: -



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Project name : -
Grant ID : 1R01MH126213
Funding program : -
Funding organization : National Institute of Mental Health
Project name : -
Grant ID : 1715202
Funding program : -
Funding organization : National Science Foundation
Project name : -
Grant ID : 777394
Funding program : -
Funding organization : Innovative Medicines Initiative
Project name : -
Grant ID : R01MH118217, K01MH104592, R01MH126213, R01MH116147, P41EB015922 and P41EB015922
Funding program : -
Funding organization : National Institute of Health

Source 1

Title: Frontiers in Psychiatry
  Abbreviation : Front Psychiatry
Source Genre: Journal
Publ. Info: Lausanne, Switzerland : Frontiers Research Foundation
Pages: - Volume / Issue: 13 Sequence Number: 958688 Start / End Page: - Identifier: ISSN: 1664-0640
CoNE: https://pure.mpg.de/cone/journals/resource/16640640