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  Considerations on gradual glutamate accumulation related to cognitive task performance

Möller, H. E. (2022). Considerations on gradual glutamate accumulation related to cognitive task performance. Journal of Cerebral Blood Flow and Metabolism. doi:10.1177/0271678X221139550.

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Moeller_2022.pdf (Publisher version), 224KB
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 Creators:
Möller, Harald E.1, Author           
Affiliations:
1Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              

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Free keywords: Cognitive fatigue; Excitotoxicity; Glutamate; Magnetic resonance spectroscopy; Neurotransmitter cycling
 Abstract: Long-lasting activities with high demand in cognitive control are known to result in cognitive fatigue. However, the reason for control cost inflation remains elusive. A neurometabolic account was proposed in a recent study combining magnetic resonance spectroscopy (MRS) with daylong execution of behavioral tasks. It suggests that control cost during high-demand work is related to the necessity of recycling potentially toxic substances, specifically glutamate, which may accumulate extracellularly. As MRS provides estimates of metabolite concentrations, further evaluations are possible how well this hypothesis fits with fundamental consequences from the dynamic equilibrium of intercompartmental glutamate distributions.

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Language(s): eng - English
 Dates: 202220222022-11-11
 Publication Status: Published online
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 Rev. Type: -
 Identifiers: DOI: 10.1177/0271678X221139550
Other: online ahead of print
PMID: 36369737
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Title: Journal of Cerebral Blood Flow and Metabolism
Source Genre: Journal
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Publ. Info: New York : Lippincott Williams & Wilkins
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 0271-678X
CoNE: https://pure.mpg.de/cone/journals/resource/954925503202